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Application of rapamycin in preparing medicines for treating addiction to morphine-like drugs

A technology of rapamycin and drugs, applied in the field of rapamycin in the preparation of drugs for the treatment of morphine drug addiction, can solve the problem of not finding rapamycin, etc., and achieve good results

Inactive Publication Date: 2009-06-03
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] No reports on the use of rapamycin in the preparation of drugs for the treatment of drug addiction and prevention of relapse were found after searching

Method used

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  • Application of rapamycin in preparing medicines for treating addiction to morphine-like drugs
  • Application of rapamycin in preparing medicines for treating addiction to morphine-like drugs
  • Application of rapamycin in preparing medicines for treating addiction to morphine-like drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Method for establishing a rat model of morphine addiction

[0023] The present invention adopts conditioned place preference (CPP for short) training mode to establish a rat morphine addiction model. The relevant description is as follows:

[0024] The conditioned position preference training and testing instrument is a conditioned position preference box composed of three boxes (developed by the Institute of Materia Medica, Chinese Academy of Medical Sciences): two side chambers (L×W×H: 27.9cm×21cm×20.9cm) and one The middle room (L×W×H: 12.1cm×21cm×20.9cm). The three rooms are separated by movable partitions, and the floors are similar.

[0025] Basic value test: This experiment uses an unbiased design. On the first day, Sprague-Dawley (SD) male rats (purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2002-2003, weight 200-220g) were put into the middle room, Allow him to move freely in the three rooms for...

Embodiment 2

[0029] Example 2: Intraventricular administration of rapamycin to inhibit morphine addiction behavior in rats

[0030] Forty male SD rats (purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.) were randomly divided into two groups, and the conditional positions of physiological saline (1ml / kg, ip) or morphine (10mg / kg, ip) were carried out respectively. Preference training (the method is the same as in Example 1), 60 minutes before each training, each group (20 animals / group) is divided into 2 groups (10 animals / group), respectively, given intraventricular injection of 300μg of rapamycin or solvent DMSO, and observe The formation of CPP. The specific groups are as follows: (1) Normal saline + vehicle control group: Normal saline for CPP training, intraventricular injection of solvent DMSO (n=10) 60 minutes before training; (2) Normal saline + rapamycin group: Normal saline for training For CPP training, 300μg of rapamycin (n=10) was given to the ventricle 60...

Embodiment 3

[0032] Example 3: Test of the effect of intracerebroventricular administration of rapamycin on spontaneous activity in rats

[0033] Sixteen rats were randomly divided into two groups, each with 8 rats. One group was injected with 300μg rapamycin into the ventricle, and the other group was injected with DMSO as a solvent. One hour later, they were placed in an autonomous activity test box (purchased from Shanghai Jiliang Software). Technology Co., Ltd.), a computer program automatically observes and records the total number of activities of the rats, which is recorded every 5 minutes for a total of 60 minutes.

[0034] Result (see figure 2 ) After intracerebroventricular injection of rapamycin or solvent DMSO, the spontaneous activity of rats gradually decreased over time (F (11，191) =74.576, p(1，191) =1.785, p>0.05), there is no interaction between the drug and time (F (11，191) =0.656, p>0.05). It shows that rapamycin does not affect the spontaneous activities of rats.

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Abstract

The invention discloses an application of rapamycin in preparing medicines for treating addiction to morphine-like drugs. The invention provides an effective method for treating addiction to morphine-like drugs and preventing addicts taking morphine-like drugs again after detoxication of morphine-like drugs. The medicines have good therapeutic effect, and are hopeful to completely eliminate the psychological dependence of people addiction to morphine-like drugs.

Description

Technical field [0001] The invention relates to the use of rapamycin in the preparation of drugs for treating morphine drug addiction. Background technique [0002] Drug addiction is a public health and social problem that plagues human health and social development. It severely endangers human health and affects family stability and social development. For example, among the newly infected cases of AIDS in my country in 2007, about 42% of patients were related to drug addiction and abuse. [0003] Drug addiction is a chronic and highly recurring complex brain disease. It is characterized by a progressive development from impulsive drug-seeking caused by initial drug use to compulsive drug-seeking, forming a strong physical and mental dependence. Detoxification treatment for physical dependence has accumulated rich clinical experience, such as drug treatments such as buprenorphine, methadone and naltrexone, as well as surgical treatments such as radiofrequency thermocoagulation d...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61P25/36
Inventor 陆林时杰李艳琴张肖丽朱维莉史海水
Owner PEKING UNIV
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