Compound scutellaria microemulsion formulation and preparation method thereof
A technology of compound scutellaria baicalensis and emulsion preparation, which is applied in the directions of pharmaceutical formulation, emulsion delivery, and medical preparations of inactive ingredients, etc., can solve the problems of low bioavailability of oral preparations, affecting the curative effect of the prescription, poor water solubility of baicalin, etc. The effect of convenient storage and administration, easy absorption, and simple preparation method
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Embodiment 1
[0026] Weigh 1.17 g of Scutellaria baicalensis extract, add 2 g of caprylic acid triglyceride, 13.3 g of polyoxyethylene hydrogenated castor oil, 6.67 g of 1,2-propanediol, stir evenly (40°C), add the corresponding extracts of honeysuckle and forsythia , continue to add dropwise water to an appropriate amount, adjust the pH value to 7.0 with sodium hydroxide, add water to 100ml, and stir well. Refrigerate for 24 hours. Filter and add water to full volume. Fill, sterilize, and get ready.
[0027] The preparation of Scutellaria baicalensis extract:
[0028] Scutellaria baicalensis pieces were boiled three times with water. Combine the decoction, filter, add hydrochloric acid solution to adjust pH value to 1~2 after filtrate concentration, keep warm for 1 hour, let stand, filter, add water to precipitate and mix, adjust pH value to 7.0 with 40% sodium hydroxide, then add etc. amount of ethanol, stirring to dissolve and filter. The filtrate was adjusted to pH 2 with hydrochlo...
Embodiment 2
[0032] Weigh 2 g of caprylic acid triglyceride, 13.3 g of polyoxyethylene hydrogenated castor oil, 6.67 g of 1,2-propanediol and the extracted volatile oil, stir evenly (40°C), add Scutellaria baicalensis, Forsythia suspensa, and honeysuckle extract, continue Add water dropwise to an appropriate amount, adjust the pH to 7.0 with sodium hydroxide, add water to the full amount, and stir well. Refrigerate for 24 hours. Filter and add water to 100ml. Fill, sterilize, and get ready. The preparation of Scutellaria baicalensis, Forsythia suspensa, honeysuckle extract and volatile oil:
[0033] Weigh 30 g of Scutellaria baicalensis, 60 g of Forsythia suspensa, and 30 g of honeysuckle and boil for 3 times, and collect the volatile oil at the same time for the first time. Combine the decoction and concentrate. Ethanol was added to make the alcohol content reach 60%, left standing, filtered, and ethanol was recovered from the supernatant until there was no alcohol smell. spare.
Embodiment 3
[0035] Weigh 1.17 g of Scutellaria baicalensis extract, add 2 g of soybean oil, 15.0 g of polysorbate 80, and 9.67 g of glycerol, stir well, add the corresponding extracts of honeysuckle and forsythia, continue to add water to an appropriate amount, add 30 g of sugar, and stir to make Dissolve the sugar, adjust the pH to 7.0 with sodium hydroxide, add water to the full amount, and stir well. Refrigerate for 24 hours. Filter and add water to 100ml. Fill, sterilize, and get ready.
[0036] Wherein, the preparation methods of Scutellaria baicalensis extract and Lonicerae Forsythia extract are the same as those in Example 1.
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