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Composite valerian extract capable of tranquilizing and allaying excitement and production method thereof

A technology of valerian extract and compound valerian, applied in medical preparations containing active ingredients, food science, food preparation, etc.

Inactive Publication Date: 2009-04-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in ancient and modern times, there are no extracts compatible with the prescription of these two herbs, and there are no reports of clinical use, nor are there reports on the combination of these two herbs for the prevention and treatment of insomnia.

Method used

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  • Composite valerian extract capable of tranquilizing and allaying excitement and production method thereof
  • Composite valerian extract capable of tranquilizing and allaying excitement and production method thereof
  • Composite valerian extract capable of tranquilizing and allaying excitement and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Combined extraction method to prepare the extract of the present invention

[0047] (1) Preparation of extract

[0048] Take 2kg of valerian coarse powder and 2kg of Schisandra chinensis coarse powder, soak them in 4000ml95% ethanol, place overnight, percolate according to the routine, control the percolation speed at 3-5ml / min, add solvent at any time during the percolation process, and percolate until the total valerian The percolate is collected until the assay reaction of the grass element and total lignans is negative, which is the extract. Concentrate to a small volume, dilute with distilled water, pass through a pretreated AB-8 macroporous adsorption resin column, and elute with 6 times the amount of 90% ethanol. Collect the eluate. Resin pretreatment: wash away the fine resin and broken resin with double distilled water first, after wet packing, soak in absolute ethanol 10cm higher than the resin layer for one day, release the immersion liquid, conti...

Embodiment 2

[0059] Valerian root and Schisandra chinensis were mixed at 3:2, crushed into coarse powder, 4000g was taken, and 8 times the amount of 95% ethanol was refluxed and extracted 3 times for 2 hours each time, and the rest were the same as in Example 1 to obtain 153.2g of extract powder. Taking Schisandrin A as an index, the total lignan content was determined by spectrophotometry to be 8.9%, and the valerian content was used as an index to determine the total valerian content by HPLC method to be 28.5%.

Embodiment 3

[0060] Example 3 Combined extraction method to prepare the extract of the present invention

[0061] Valerian and Schisandra were mixed at 2:3, crushed into coarse powder, 4000g was taken, and 8 times the amount of 60% ethanol was refluxed and extracted 3 times, each time for 2 hours, and the rest were the same as in Example 1 to obtain 142.3g of extract powder. Taking schisandrol A as an index, the total lignan content was determined by spectrophotometry to be 14.4%, and the valerian content was used as an index, and the total valerian content was determined by HPLC to be 20.8%.

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PUM

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Abstract

A compound valerian extract for tranquilizing and allaying excitement is made from 1-5 parts by weight of valerian extract and 1-5 parts by weight of magnolia vine fruit extract by a combined extraction method and a separated extraction method; the combined extraction method is as follows: coarse powder of various bulk drugs are mixed proportionally, the mixture is percolated or refluxed with an extraction solvent to obtain extracting solution, the extracting solution is depressurized to recover the extracting solvent until no smell of ethanol exists, the solution is filtered to obtain filtrate which is diluted and eluted on a macroporus adsorbent resin column with 60-90% of ethanol which is six times of the volume of the column, and the eluent is dried to obtain the extract; the separated extraction method is as follows: coarse powder of various bulk drugs, namely, the valerian and magnolia vine fruit are respectively percolated or refluxed with the extracting solvent to obtain various extracting solutions, the extracting solutions are respectively depressurized to recover the extracting solvent until no smell of ethanol exists, the solution is filtered to obtain the filtrate which is diluted and eluted on a macroporus adsorbent resin column with 60-90% ethanol which is six times of the volume of the column, the eluent is dried to obtain the extract, and the compound valerian extract is obtained by mixing the obtained valerian extract and magnolia vine fruit extract; and the extracting solution is 45-95% ethanol water solution. The compound valerian extract can be used for preparing medicines or foods for tranquilizing and allaying excitement, preventing and treating insomnia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound sedative and tranquilizer preparation and a preparation method thereof, more specifically, it relates to a compound composed of valerian medicinal materials as the main agent and supplemented with schisandra chinensis, and is prepared into a preparation by a modern preparation method for preventing and treating mild and moderate Degree of insomnia. Background technique [0002] Good sleep is the basis for ensuring work efficiency and quality of life, and it is also an important symbol of physical and mental health. Long-term insomnia will lead to diseases such as anxiety and depression, and further aggravate the symptoms of insomnia. According to the statistics of the World Health Organization, about 1 / 4 of the world has suffered from insomnia to varying degrees. The incidence of insomnia in my country has reached 20%, and the number of middle-aged and elderly people with poor sleep qual...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/84A61P25/20A23L1/30A23L33/105
Inventor 黄宝康黄流清秦路平赵忠新张巧艳
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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