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Medicine composition of aconitum pendulum non-alkaloids active site and preparation method thereof

A non-alkaloid, active site technology, applied in the field of preparation of a non-alkaloid active site pharmaceutical composition with a hammer, can solve the problem of no patent application for non-alkaloid components, no relevant reports on the pharmacological effects of non-alkaloid components, etc. question

Inactive Publication Date: 2009-03-25
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the chemical composition of the iron rod hammer used in medicine is also concentrated on alkaloids, and there is no patent application for non-alkaloid components; the pharmacological effects of iron rod hammers are almost all concentrated on alkaloid components, and there is no patent application for non-alkaloid components. There is no relevant report on the pharmacological effects of similar ingredients

Method used

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  • Medicine composition of aconitum pendulum non-alkaloids active site and preparation method thereof
  • Medicine composition of aconitum pendulum non-alkaloids active site and preparation method thereof
  • Medicine composition of aconitum pendulum non-alkaloids active site and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]Take the medicinal material that has been dried to constant weight with an iron bar hammer, crush it, pass through a 16-mesh sieve, weigh 100g, add 500mL 70% ethanol to reflux for extraction for 1.5h, cool, filter, add 500mL of 70% ethanol to reflux and extract for 1.5h, and repeat. Extracted 3 times and combined the 3 extraction filtrates. Concentrate under reduced pressure to a fluid extract with a relative density of 1.5-2. Weigh the fluid extract according to the same weight as the macroporous adsorbent resin, separate it through the macroporous adsorbent resin, and first elute it with water until the eluent is colorless to obtain the water-washed part, and then elute it with 50% ethanol until it is washed. The part washed with 50% ethanol was washed with 50% ethanol, and finally eluted with 95% ethanol until the eluate was colorless, and the part washed with 95% ethanol was obtained. Take 1-2 mL of water-washed parts, 50% ethanol-washed parts and 95% ethanol-washed...

Embodiment 2

[0036] The same as Experimental Example 1, wherein the extraction solvent is 2000mL water, reflux extraction for 3h, extraction twice, the two extraction filtrates are combined, concentrated under reduced pressure to obtain a liquid extract. Weigh the liquid extract according to the same weight as the macroporous adsorbent resin, separate it through the macroporous adsorbent resin, and first elute it with water until the eluent is colorless to obtain the water-washed part, and then elute it with 30% ethanol until it is washed. The part washed with 30% ethanol was obtained after the eluate was colorless, and finally eluted with 80% ethanol until the eluate was colorless, and the part washed with 80% ethanol was obtained. Take 1-2 mL of water-washed parts, 30% ethanol-washed parts, and 80% ethanol-washed parts respectively, add 1-2 drops of bismuth potassium iodide test solution, and the alkaloid precipitation reaction of water-washed parts and 30% ethanol-washed parts appears or...

Embodiment 3

[0038] Same as Experimental Example 1, wherein the extraction solvent is 500 mL of acetic acid aqueous solution with a pH value of 2-6, reflux extraction for 1 hour, and extraction once. Concentrate under reduced pressure to obtain a liquid extract. Weigh the liquid extract according to the same weight as the macroporous adsorbent resin, separate it through the macroporous adsorbent resin, and first elute it with water until the eluent is colorless to obtain the water-washed part, and then elute it with 40% ethanol until it is washed. The colorless eluent was washed with 40% ethanol, and finally eluted with 100% ethanol until the eluate was colorless to be washed with 100% ethanol. Take 1-2mL water-washed parts, 40% ethanol-washed parts and 100% ethanol-washed parts respectively, and add 1-2 drops of bismuth potassium iodide test solution respectively, and the alkaloid precipitation reaction in water-washed parts and 40% ethanol-washed parts appears orange-yellow Flocculent p...

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Abstract

Disclosed is a medicine combination of effective fraction of aconitum pendulum non-alkaloid, and the preparation method thereof. The invention discloses a medicine combination of non-alkaloid effective fraction of aconitum pendulum, which is used for anti-inflammatory and analgesia, and the preparation method thereof; wherein, the non-alkaloid effective fraction of aconitum pendulum is extracted from the raw material of aconitum pendulum; the non-alkaloid effective fraction of aconitum pendulum has good anti-inflammation and analgesic effects; the non-alkaloid effective fraction of aconitum pendulum can be combined with pharmaceutical excipient to prepare medicine combination which can be made into capsules or tablets, etc.

Description

Technical field: [0001] The pharmaceutical composition of the non-alkaloid active part of the iron rod hammer and the preparation method thereof of the present invention is a kind of non-alkaloid active part of the Ranunculaceae plant Phytophthora erbaticum for anti-inflammatory and analgesic, especially relates to the non-alkaloid active part of the iron rod hammer A preparation method of a pharmaceutical composition of an alkali active site. Background technique: [0002] The iron rod hammer is the dry root tuber of the Ranunculaceae plant Acontium flavum Hand-Mazz. "Chinese Dictionary" records: "Iron rod hammer, promoting blood circulation and removing blood stasis, expelling wind and dampness, relieving pain, and reducing swelling." Muscle growth by putrefaction, hemostasis." Most of the research on the chemical composition of the iron rod hammer focuses on alkaloids. Currently, there are 8 alkaloids reported, namely aconitine, 3-acetylaconitine, North China aconitine,...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/20A61K9/48A61P29/00A61K125/00
Inventor 付雪艳董琳马学琴戴贵东周文韬张立明张义伟
Owner NINGXIA MEDICAL UNIV
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