Nutritional composition for low birth weight infants

A nutritional composition and a technology for the composition, applied in the field of nutritional compositions, can solve the problems of amino acid metabolism limitation, amino acid imbalance and the like

Active Publication Date: 2009-03-04
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, premature infants can also suffer from restricted metabolism of some amino acids, such as phenylalanine, which can lead to severe amino acid imbalances if protein intake exceeds the capacity for degradation
On the other hand, the availability of essential amino acids can be a limiting factor for protein synthesis and thus growth

Method used

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  • Nutritional composition for low birth weight infants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] An example of the nutritional composition of the present invention is as follows:

[0058] Calorie density (kcal / 100ml) 80

[0059] Protein g / 100 kcal 3.6

[0060] Protein Hypoallergenic Hydrolyzed Whey Protein

[0061] DH 14

[0062] (as protein) 1.4% free arginine

[0063] (Protein) 1.9% free histidine

[0064] Fat g / 100 kcal 5.2

[0065] in:

[0066] MCT 40%

[0067] Interesterified palm oil 11% (56% of Sn2 position is palmitic acid)

[0068] ARA0.6%

[0069] DHA 0.3%

[0070] n6:n3 8.2:1

[0071] ARA:DHA 2:1

[0072] Sugar g / 100 kcal 9.9

[0073] Lactose / maltodextrin 40 / 60

[0074] Electrolytes & inorganics per 100 kcal

[0075] Na (mg) 64

[0076] K (mg) 136

[0077] Cl (mg) 95

[0078] Ca (mg) 150

[0079]P (mg) 88

[0080] Ca / P 1.7

[0081] Mg (mg) 10

[0082] Mn(μg) 7.0

[0083] Vitamins & trace elements per 100 kcal

[0084] A(IU...

Embodiment 2

[0112] This example compares the effect of a nutritional composition of the invention, which was used as the sole source of nutrition for a group of premature infants, and a control nutritional composition on protein utilization, metabolic state and growth. The composition of the formulation is given in the table below:

[0113] Table 1. Composition of the studied formulations ( / 100 kcal) ＊

[0114]

[0115] The recipes differed mainly in protein content (3.0 v 3.6g / 100k cal). Other differences emerged in carbohydrate (10.5 v 9.9g), electrolytes (see above), vitamin A (350 v 500IU) and iron (1.5mg v 0) content.

[0116] The study was prospective, double-blind, randomized, and virtually each infant was swap-fed with two formulas. The order of formula feeding was predetermined in a balanced random pattern. Infants randomized to Sequence A were fed first the experimental protein formula and then the control protein formula. Infants randomized to sequence B ...

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PUM

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Abstract

A nutritional composition for very low birth weight infants which comprises 26 5 to 38 g / l of a source of hypoallergenic hydrolysed whey protein with a degree of hydrolysis between 8 and 20, 37 to 46 g / l of a fat source of which 20 to 50% is medium chain triglycerides and which has an n6:n3 ratio between 6 and 12 and 50 to 100 g / l of a carbohydrate source which composition contains between 3.2 and 4.0 grams of protein per 100kcal.

Description

field of invention [0001] The present invention relates to nutritional compositions for very low birth weight premature infants, and methods for meeting the nutritional needs of such infants. Background of the invention [0002] Breast milk is recommended for all babies. However, in some cases (particularly in the case of premature infants), breastfeeding may be insufficient or unsuccessful or not recommended, or even impossible, for medical reasons. Infant formulas have been developed for these conditions. [0003] Preterm babies are babies born before the 37th full week of pregnancy. Such infants generally show functional immaturity, and the greater the degree of advance, the more significant the functional immaturity. This immaturity is manifested in several ways. For example, premature infants are likely to have an immature gastrointestinal tract, especially with regard to the ability to absorb nutrients, and the development and effectiveness of the intestinal barrie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L33/00
CPCA23V2002/00A23L1/296A23L33/40A23V2250/1944A23V2250/1862A23V2250/1868A23V2250/1612A23V2250/1592A23V2250/1598A23V2250/1588A23V2250/1642A23V2250/1626A23V2250/70A23V2250/702A23V2250/71A23V2250/712A23V2250/7142A23V2250/7042A23V2250/7044A23V2250/7046A23V2250/7048A23V2250/705A23V2250/7054A23V2250/7058A23V2250/706A23V2250/641A23V2250/0644A23V2250/0612
Inventor F·哈施克C·R·马廖拉
Owner SOC DES PROD NESTLE SA
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