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Method for extracting total lactones from auckandia root and quality control method thereof

A technology of dehydrocresinolide and total lactone, applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of easy introduction of impurities, inapplicability to large-scale production, and large loss of volatile oil and active ingredients and other issues to achieve good therapeutic effect

Inactive Publication Date: 2009-02-04
李明海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are many extraction methods for volatile oil, and the yield of water extraction process is low; the alcohol extraction process will cause a large loss of volatile oil and active ingredients, and it is easy to introduce impurities; microwave extraction and ultrasonic extraction are currently limited to small-scale laboratory operations. Not suitable for mass production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Get 500g of cassava crude powder and place it in the extractor, and use CO 2 Get rid of the air in the extractor, adjust the pressure and temperature of the extractor and separator, the extraction temperature is 25°C, the extraction pressure is 10Mpa, CO 2 Under the condition of flow rate of 21-25L / h, continuous extraction for 2 hours, analysis under the condition of pressure of 5Mpa and temperature of 35°C, extract brown-red or brown-yellow translucent oil, take the extract from the separator, and centrifuge Moisture is removed to obtain the total lactones of woody wood. The extraction rate is 3.32%, the total lactone content is 60.2%, and the content of dehydrocressin is 31.9%.

Embodiment 2

[0036] Get 500g of cassava crude powder and place it in the extractor, and use CO 2 Get rid of the air in the extractor, adjust the pressure and temperature of the extractor and separator, the extraction temperature is 35°C, the extraction pressure is 10Mpa, CO 2 Continuous extraction for 4 hours at a flow rate of 21-25L / h, analysis at a pressure of 6Mpa and a temperature of 40°C, extract brown-red or brown-yellow translucent oil, take the extract from the separator, and centrifuge Moisture is removed to obtain the total lactones of woody wood. The extraction rate is 2.86%, and the total lactone content is 58.1%. , the content of dehydrocosmolide is 30.8%.

Embodiment 3

[0038] Get 500g of cassava crude powder and place it in the extractor, and use CO 2 Get rid of the air in the extractor, adjust the pressure and temperature of the extractor and separator, and the extraction temperature is 40°C, the extraction pressure is 25Mpa, CO 2 Under the condition of a flow rate of 21-25L / h, continuous extraction for 3 hours, analysis at a pressure of 6Mpa and a temperature of 40°C, a brown-red or brown-yellow translucent oil is extracted, and the extract is taken out from the separator and centrifuged Moisture is removed to obtain the total lactones of woody wood. The extraction rate is 2.60%, the total lactone content is 54.2%, and the dehydrocressine content is 28.7%.

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Abstract

The invention provides a method for extracting total lactones from costus root by a CO2 supercritical extraction technology and a quality control method thereof. In the invention, the extraction pressure is 10-25MPa, the extraction temperature is 25-40 DEG C, and the extraction time is 2-4 hours, and analysis is carried out at an air pressure of 5-6MPa and a temperature of 34-40 DEG C. The method solves the disadvantages of the conventional extraction process that the operating temperature is relatively high, thermosensitive substance is easy to be oxidized and dissipated, high boiling point substance is not easy to be fully extracted, the yield is low, etc. In an extract of the invention, the content of dehydrocostus lactone is higher than 20%, and the total content of costundide and dehydrocostus lactone is higher than 50%.

Description

technical field [0001] The invention relates to a preparation method for extracting total lactones of xanthus chinensis for treating gastric motility disorder from traditional Chinese medicine xanthus chinensis, and a quality control method of the extract prepared by the method. It belongs to the field of medical technology. Background technique [0002] Gastric motility disorder is a common and frequently-occurring disease in clinical practice. In my country, with social development, environmental changes, population structure and changes in people's lifestyles, the incidence of stomach problems mainly caused by smoking, drinking, emotional stress, drug stimulation, etc. has gradually increased. On the other hand, stomach discomfort and gastric motility problems caused by social pressure and work-related reasons such as irregular eating and irregular eating are also on the rise. [0003] For a long time, chemical drugs have played the leading role in the treatment of gast...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61P1/14A61K125/00
Inventor 唐星田兰赵立新李明海高子彬马海波
Owner 李明海
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