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Method for preparing scalding model of New Zealand rabbit

A technology of model and gauze, which is applied in the field of preparing New Zealand rabbit scald model, can solve the problems that the degree of burn cannot be truly reflected, and the degree of burn on the wound surface is different, so as to achieve accurate control of burn area and depth, easy deformation, and good repeatability Effect

Inactive Publication Date: 2009-01-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The imbalance of the thermal injury process leads to different degrees of burns on the wound surface, which cannot truly reflect the actual degree of burns.

Method used

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  • Method for preparing scalding model of New Zealand rabbit
  • Method for preparing scalding model of New Zealand rabbit
  • Method for preparing scalding model of New Zealand rabbit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the embodiments and accompanying drawings.

[0016] Experimental Materials

[0017] 96 adult male New Zealand rabbits (Experimental Animal Center, Fourth Military Medical University) were selected, weighing 2kg to 500g. OLYMPUS CX31 microscope and camera system (Japan), LEICA-2135 rotary microtome (Germany), paraffin embedding microtome (Shanghai), BCD-218WH constant temperature water tank (Guangzhou), long straight forceps, medical gauze.

[0018] experimental method

[0019] Detection of gauze insulation degree - prepare 25 layers, 30 layers, 35 layers and 40 layers of gauze of 3cm×3cm respectively, clamp both sides with long straight pliers, put them in a water bath at 99°C for 5 minutes, and then put them in 35 Stay on the absorbent cotton with heat preservation at ℃ for 21 seconds, use a thermometer to detect the gauze piece with the best heat preservation effect as a scald tool, ...

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Abstract

The invention discloses a method used for preparing a New Zealand rabbit scald model, which comprises the steps as follows: medical gauze is used as a hot carrier; firstly, the optimum gauze layer number, by which the heat can be continuously kept, is determined; the gauze which is heated to 99 DEG C in constant-temperature water is respectively used for scald the back of the New Zealand rabbit AT by 12 time points of 3-25s; samples are obtained 24 hours after the scald; the scald degree is evaluated by HE staining; furthermore, corresponding analysis of the time and degree of scald is carried out; scald models as follows are established according to different scald time: the scald model of level-I with the scald time of 3-5s, the scald model of level-shallow-II with the scald time of 7-13s, the scald model of level-deep-II with the scald time of 15-19s, and the scald model of level-III with scald time of 21-25s. The method of the invention has the advantages of exact control of scald area and depth, simple and convenient operation and good repeatability, and the model prepared by the method is a good model used for researching scald restoration mechanism.

Description

technical field [0001] The invention relates to a method for preparing an animal scald model, in particular to a method for preparing a New Zealand rabbit scald model. Background technique [0002] Establishing animal scald models is an extremely important experimental method and means for studying burn wound repair and medication. An ideal model will help to understand more scientifically and accurately the development and evolution of various body systems and local wounds after burns, and explore targeted prevention and treatment measures. Most of the current animal models of burns and scalds focus on rats. Although there are reports on the use of rabbits such as New Zealand rabbits as animal models of burns and scalds, the experimental conditions reported vary greatly and cannot be used as a general indicator. [0003] Practical animal scald model is the premise of researching scald medicine and treatment method. Due to the large size of New Zealand rabbits, in the bur...

Claims

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Application Information

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IPC IPC(8): G09B23/36
Inventor 刘利兵于军曲萍张学策周幸春铁茹杨芳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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