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Process for preparing low polymerized chitosan

A technology of chitooligosaccharides and chitosan, which is applied in the field of preparation of chitin derivatives in organic polymer compounds, can solve the problems of not meeting the requirements of drug ash content, high ash content, high heavy metal content, etc.

Active Publication Date: 2009-01-07
杭州仟源保灵药业有限公司
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AI Technical Summary

Problems solved by technology

Due to the incomplete decalcification of chitin or chitosan during processing and the high content of heavy metals in the raw materials, the ash content of the chitooligosaccharides obtained by this method is relatively high, usually 1.4 by weight. % or so, can not meet the ash requirements of drug standards

Method used

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Embodiment Construction

[0013] 1. The preparation method of the chitooligosaccharide provided by the present invention comprises adding water and mixing the chitosan, adding acid to dissolve it, enzymatic hydrolysis, and then filtering to obtain a chitooligosaccharide solution, wherein the chitosan is first treated with EDTA sodium salt. That is, the preparation method is that chitosan is first stirred in EDTA sodium salt solution and then filtered to obtain chitosan treated with EDTA sodium salt solution, then mixed with water, dissolved in acid, and then enzymatically hydrolyzed and filtered to obtain chitosan oligomerization. sugar solution, then concentrated and spray-dried to obtain low ash chitooligosaccharides.

[0014] Add 20g of EDTA sodium salt into 20kg of purified water to form a 0.1% solution, then add 5kg of chitosan, stir at room temperature for half an hour, and filter. Add 20 kg of purified water to the precipitate, stir for 15 minutes, and filter. Add 45kg of purified water, 2kg of...

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Abstract

The invention provides a preparation method for chitosan-oligosaccharide; after the chitosan-oligosaccharide is added with water and mixed uniformly, acid is added for dissolving; after enzymolysis and filtering, a chitosan-oligosaccharide liquid is obtained; wherein, the chitosan-oligosaccharide is firstly processed by EDTA sodium salt. The preparation method includes as follows: after the chitosan-oligosaccharide is firstly stirred in the liquid of the EDTA sodium salt, the chitosan-oligosaccharide is filtered to obtain the chitosan-oligosaccharide processed by the liquid of the EDTA sodium salt; then the acid is added for dissolving after the water is added and uniformly mixed; then the chitosan-oligosaccharide is obtained after enzymolysis and filtering; the chitosan-oligosaccharide with low ash content is obtained after being condensed and dried by spraying. The preparation method for chitosan-oligosaccharide provided by the invention firstly uses the EDTA sodium salt liquid to process before acid dissolving is carried out on the chitosan-oligosaccharide and utilizes the characteristic of the EDTA sodium salt which can chelate a plurality of cations to form a complex compound to remove the calcium and micro-heavy metals that are not removed from the chitosan-oligosaccharide so as to reach the effects of reducing the ash content and increasing the white color. Detected according a weight method, the ash content of the chitosan-oligosaccharide prepared by the preparation method of the invention is lower than 0.6 percent.

Description

technical field [0001] The invention relates to a method for preparing chitosan oligosaccharides, which belongs to the method for preparing chitin derivatives in organic macromolecular compounds. Background technique [0002] Chitooligosaccharide is a low molecular weight (Chitooligosaccharide) chitosan, also known as chitosan oligosaccharide, the chemical name is 2-amino-β-1,4-glucosamine, and the molecular formula is (C 6 h 11 o 4 N) n, the degree of polymerization is below 25-30. Chitooligosaccharides have unique and superior physiological activities and functional properties, and are widely used. Especially in medicine, chitooligosaccharides have various physiological functions and anticancer effects, especially chitosan has strong physiological activity, and can be used as a therapeutic drug for early cancer, which can inhibit the formation of cancerous capillary endothelium and cause cancer. The swollen capillary cannot be lengthened and is limited to the local eff...

Claims

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Application Information

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IPC IPC(8): C12P19/04
Inventor 郑婵颖郑海龙
Owner 杭州仟源保灵药业有限公司
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