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Antidepressant drug using paeoniflorin as raw material and production method thereof

A technology of paeoniflorin and drugs, which is applied in the field of drugs for the treatment of depression, and can solve problems such as slow onset time

Inactive Publication Date: 2008-12-31
张作光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the existing mainstream antidepressant drugs have a slow onset time

Method used

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  • Antidepressant drug using paeoniflorin as raw material and production method thereof
  • Antidepressant drug using paeoniflorin as raw material and production method thereof
  • Antidepressant drug using paeoniflorin as raw material and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] See attached figure 1 10 kilograms of Radix Paeoniae Alba (conforming to the provisions of "The Pharmacopoeia of the People's Republic of China") were broken and soaked at room temperature for 12 hours, extracted with water and alcoholized, concentrated and dried to obtain 1.5 kilograms of Radix Paeoniae Alba extract (the yield of paste was 15%). Phase detection contains 0.16 kg of paeoniflorin, an antidepressant drug with post-receptor action mechanism of the present invention (the purity of paeoniflorin in the Radix Paeoniae Alba extract is 11%).

Embodiment 2

[0038] See attached figure 2 , 10 kilograms of Radix Paeoniae Alba (according to the provisions of "The Pharmacopoeia of the People's Republic of China") were broken and soaked at room temperature for 12 hours, extracted with water and precipitated with alcohol, concentrated, separated by column chromatography, and dried to obtain 0.40 kg of Radix Paeoniae Alba extract (the paste yield was 4%), containing 0.16 kg of antidepressant paeoniflorin of the present invention through HPLC detection (purity of paeoniflorin in the Radix Paeoniae Alba extract ≥ 40%).

Embodiment 3

[0040] Directly use 20 g of paeoniflorin with 98% purity plus 1 times of auxiliary materials to make 100 tablets, specification: 400 mg / tablet (containing 200 mg of paeoniflorin).

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Abstract

The present invention discloses a medicine made from paeoniflorin for curing depression and the dosage thereof. The present invention has the following main technical characteristics: the effective dosage of the paeoniflorin is 80 to 400mg / day; the optimal dosage is 150 to 300mg / day; the best dosage is 220mg / day. The present invention also discloses the preparation method of the medicine. The experiment proves that the medicine provided by the present invention can obviously reduce tail suspension fixed time and reserpine-induced temperature dropping of tested mice, thus concluding that the medicine provided by the present invention has the efficacy of experimental depression resistance.

Description

technical field [0001] The invention relates to a medicine for treating depression made of paeoniflorin as a raw material, which can be used as medicine, nutritional agent and health food. [0002] The present invention also relates to the preparation method of the above-mentioned medicine for treating depression. Background technique [0003] Depression is a common illness. According to statistics, about 25% of women in the general population have experienced depression in their lifetime, and about 10% of men have experienced depression (Zhang Chunxing: "Modern Psychology"). Information provided by the World Health Organization: The incidence of depression in the world is about 11%. There are currently about 340 million mentally depressed patients in the world, and this number is still on the rise. The survey found that depression will increase in the next 20 years It is the second most common disease worldwide. [0004] At present, serotonin reuptake inhibitors (SSRIs) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/71A61P25/24A61K125/00
CPCA61K9/20A61K31/7048A61P25/20A61P25/22A61P25/24A61P43/00
Inventor 张作光
Owner 张作光
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