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Compound atenolol tablet and preparation method thereof

A technology for compound atenolol tablets and excipients, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2008-12-31
SHANGHAI HUA SURNAME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with ordinary tablets, there are still some technical difficulties in the preparation process of coated tablets, especially the relationship between the hardness of uncoated tablets and the disintegration time limit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: ingredient weight or percentage content

[0025] Atenolol 500g

[0026] Chlorthalidone 125g

[0027] Calcium hydrogen phosphate 2000g

[0028] Croscarmellose Sodium 40g

[0029] Povidone (K30) 5g

[0030] Magnesium Stearate 3g

[0031] Preparation method: powder atenolol and chlorthalidone raw materials, and sieve through 80 meshes, then put them in a mixer with the prescribed amount of calcium hydrogen phosphate and croscarmellose sodium, mix well, add The povidone aqueous solution is used to make wet granules, and then enter the boiling dryer for drying. The air inlet temperature is set at 65°C, and the air outlet temperature is set at 42°C. After cooling, add magnesium stearate sieved through a 100-mesh sieve, mix for 1 minute, and discharge; then take a sample, and after passing the inspection, perform tablet compression in a production workshop that meets GMP production conditions Preparation, after passing the inspection of the plain tablet, co...

Embodiment 2

[0034] Prescription: ingredient weight or percentage content

[0035] Atenolol 500g

[0036] Chlorthalidone 125g

[0037] Calcium hydrogen phosphate 1900g

[0038] Croscarmellose Sodium 35g

[0039] Povidone (K30) 5g

[0040] Magnesium Stearate 3g

[0041] Preparation method: powder atenolol and chlorthalidone raw materials, and sieve through 80 meshes, then put them in a mixer with the prescribed amount of calcium hydrogen phosphate and croscarmellose sodium, mix well, add The povidone aqueous solution is used to make wet granules, and then enter the boiling dryer for drying. The air inlet temperature is set at 65°C, and the air outlet temperature is set at 42°C. Mesh stainless steel sieve for granulation, after cooling, add magnesium stearate sieved through 100 mesh, and then mix for 1 to 5 minutes, then discharge; then take samples, after passing the inspection, carry out in the production workshop that meets the GMP production conditions Tablet preparation, after pas...

Embodiment 3

[0043] Prescription: ingredient weight or percentage content

[0044] Atenolol 500g

[0045] Chlorthalidone 125g

[0046] Calcium hydrogen phosphate 1800g

[0047] Croscarmellose Sodium 45g

[0048] Povidone (K30) 5g

[0049] Magnesium Stearate 3g

[0050] Preparation method: powder atenolol and chlorthalidone raw materials, and sieve through 80 meshes, then put them in a mixer with the prescribed amount of calcium hydrogen phosphate and croscarmellose sodium, mix well, add The povidone aqueous solution is used to make wet granules, and then enter the boiling dryer for drying. The air inlet temperature is set at 65°C, and the air outlet temperature is set at 42°C. After cooling, add magnesium stearate sieved through a 100-mesh sieve, mix for 1 to 5 minutes, and discharge; then take samples, and after passing the inspection, carry out in a production workshop that meets GMP production conditions. Tablet preparation, after passing the inspection of plain tablets, coating is ...

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PUM

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Abstract

The present invention discloses a compound atenolol tablet and a preparation method thereof, which contains active components of atenolol and chlorthalidone, auxiliary materials and a coating outside the tablet. The weight proportion of the atenolol and the chlorthalidonem is 4:1, and the auxiliary materials contain 1 to 10 parts of disintegrant, 80 to 98 parts of bulking agent, 0.1 to 5 parts of binding agent and 0.05 to 5 parts of lubricant antiplastering agent according to the total weight of the auxiliary materials. The present invention adopts appropriate auxiliary materials and well solves the relationship among disintegrating time, hardness and coating quality of the tablet. The harness of the tablet can be up to 6.5kg and the dissolubility within 60 minutes of the atenolol and chlorthalidone should be both more than 80 percent.

Description

technical field [0001] The invention relates to a compound atenolol tablet preparation and a preparation method thereof. technical background [0002] Hypertension is a syndrome with elevated blood pressure as the main clinical manifestation. It is the etiology and risk factor of various cardiovascular and cerebrovascular diseases. The emergence of complications endangers people's health. Epidemiological surveys suggest that the current situation of hypertension in my country is the existence of "three lows", that is, low awareness rate, low treatment rate, and low control rate. Hypertension causes a large consumption of medical resources and brings a heavy economic burden to the society. Therefore, hypertension has become a social public problem. Evidence-based medical evidence shows that the benefits to hypertensive people come from the reduction of blood pressure, and effective control of blood pressure can reduce the above-mentioned complications. In view of this, act...

Claims

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Application Information

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IPC IPC(8): A61K31/4035A61K9/20A61K47/38A61P9/12A61K31/165
Inventor 毕德忠
Owner SHANGHAI HUA SURNAME PHARMA
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