Medical grade reconstructed collagen cross-linking modified method
A collagen cross-linking and cross-linking modification technology, applied in medical science, prostheses, etc., can solve the problems of cytotoxicity and difficult-to-control degradation, achieve easy cross-linking, improve mechanical properties, and control cross-linking Effect
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Embodiment 1
[0032] Add 1ml of potassium phosphate solution with a concentration of 0.1mol / L to 5ml of uniform collagen solution with a concentration of 5mg / ml at a temperature of 15°C and slowly stir, adjust the pH of the mixed solution to 7.0 with an acid or alkali solution, and mix The solution is kept at a temperature of 25°C and a humidity of 50%, and it is allowed to stand for 6 hours to make it into a uniform colloid. After the colloid is placed in an environment of -20°C and -60°C for 24 hours, it is dehydrated in a freeze dryer to obtain ions Crosslinked Modified Reconstituted Collagen.
Embodiment 2
[0034] Add 5ml of sodium phosphate solution with a concentration of 0.5mol / L to 25ml of a uniform normal collagen solution with a concentration of 10mg / ml at a temperature of 20°C and slowly stir, adjust the pH of the mixed solution to 8.5 with an acid or alkali solution, and mix The solution is kept at a temperature of 40°C and a humidity of 70%, and it is allowed to stand for 12 hours to make it into a uniform colloid. After the colloid is placed in an environment of -40°C and -80°C for 48 hours, it is dehydrated in a freeze dryer to obtain ions Crosslinked Modified Reconstituted Collagen.
Embodiment 3
[0036] Add 2ml of dipotassium hydrogen phosphate solution with a concentration of 0.2mol / L to 10ml of ordinary collagen solution with a uniform concentration of 6mg / ml at a temperature of 16°C and slowly stir, and adjust the pH value of the mixed solution to 7.2 with acid or alkali solution , the mixed solution is kept at a temperature of 28°C and a humidity of 55%, and it is left to stand for 8 hours to make it into a uniform colloid. Obtain ionically cross-linked modified collagen.
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