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Anti-heart failure pharmaceutical composition for improving skeletal muscle function and preparation method thereof

An anti-heart failure and composition technology, which is applied in drug combinations, bone diseases, and pharmaceutical formulations, can solve the problems of unsatisfactory clinical treatment results for chronic heart failure, low quality of life for heart failure patients, and no obvious reduction in fluid retention. , to protect the damaged skeletal muscle function, improve the damaged skeletal muscle function, and reduce the effect of fluid retention

Inactive Publication Date: 2011-11-16
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of understanding of the degree of attention to its harm in the relevant medical field, resulting in long-term unsatisfactory clinical treatment results for chronic heart failure, and low quality of life for heart failure patients.
[0005] At present, among the commercially available Chinese patent medicines, preparations such as Shengmai (Shenmai) and Huangqi injection are not specially designed for heart failure. Although they can improve the heart function of heart failure patients to varying degrees, they have no obvious effect on reducing fluid retention. More inconvenient for long-term use
Although Qili Qiangxin Capsules, which have been on the market in recent years, are designed for heart failure, their function of promoting blood circulation and diuresis is weak, and the capsule preparation has weak slowing effect. It is more suitable for patients with mild heart failure or stable heart failure, and acute heart failure. Difficult to rely on during exacerbations for remission; and unproved to have any protective effect against skeletal muscle damage in heart failure

Method used

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  • Anti-heart failure pharmaceutical composition for improving skeletal muscle function and preparation method thereof
  • Anti-heart failure pharmaceutical composition for improving skeletal muscle function and preparation method thereof
  • Anti-heart failure pharmaceutical composition for improving skeletal muscle function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 5 parts of raw astragalus, 2 parts of cooked aconite, 2 parts of Atractylodes macrocephala, 2 parts of white peony root, 2 parts of poria cocos, 2 parts of Sanleng, 2 parts of curcuma, 5 parts of Tinglizi, 5 parts of plantain seed, and 2 parts of Radix Ophiopogon japonicus. portion, put it in an airtight container and cook twice, adding 6-10 times the amount of water for the first time. After boiling, heat it at 80-95°C for 25-45 minutes to obtain a decoction. Add 4-8 times the amount of water for the second time, and heat it at 80-95° C. for 15-25 minutes after boiling to obtain the second decoction. Combine the secondary decoction liquids, filter, combine the filtrates, concentrate in vacuo to a relative density of 1.03-2.05 (70-90°C) to obtain extracts, add dextrin, wet granulate, and vacuum-dry to make granules.

Embodiment 2

[0032] Take 6 parts of raw astragalus, 3 parts of cooked aconite, 3 parts of Atractylodes macrocephala, 3 parts of white peony root, 3 parts of poria cocos, 2 parts of Sanleng, 2 parts of curcuma, 6 parts of Tinglizi, 6 parts of plantago seed, 3 parts of Radix Ophiopogon japonicus portion, put it in an airtight container and cook twice, adding 6-10 times the amount of water for the first time. After boiling, heat it at 80-95°C for 25-45 minutes to obtain a decoction. Add 4-8 times the amount of water for the second time, and heat it at 80-95° C. for 15-25 minutes after boiling to obtain the second decoction. Combine the secondary decoction liquids, filter, combine the filtrates, concentrate in vacuo to a relative density of 1.03-2.05 (70-90°C) to obtain extracts, add dextrin, wet granulate, and vacuum-dry to make granules.

Embodiment 3

[0034] Take 5 parts of raw astragalus, 3 parts of cooked aconite, 2.5 parts of Atractylodes macrocephala, 2.5 parts of white peony root, 3 parts of poria cocos, 3 parts of Sanleng, 3 parts of curcuma, 6 parts of Tinglizi, 5 parts of plantain seed, and 3 parts of Radix Ophiopogon japonicus portion, put it in an airtight container and cook twice, adding 6-10 times the amount of water for the first time. After boiling, heat it at 80-95°C for 25-45 minutes to obtain a decoction. Add 4-8 times the amount of water for the second time, and heat it at 80-95° C. for 15-25 minutes after boiling to obtain the second decoction. Combine the secondary decoction liquids, filter, combine the filtrates, concentrate in vacuo to a relative density of 1.03-2.05 (70-90°C) to obtain extracts, add dextrin, wet granulate, and vacuum-dry to make granules.

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Abstract

The invention pertains to the field of traditional Chinese medicine and relates to a pharmaceutical composition for improving the function of skeletal muscle and treating heart failure simultaneously and a preparation method thereof. The pharmaceutical composition aims at the pathogenesis of deficient and weak yang and qi of heart and kidney, fluid retention and blood stagnation of the heart failure and adopts the traditional Chinese medicines of raw membranous milkvetch root, prepared common monkshood daughter root, largehead atractylodes rhizome, white paeony root, Indian buead, common burreed rhizome, zedoary, pepperweed seed, plantain seed, dwarf lilyturf tuber and a pharmaceutically acceptable carrier for preparation. The pharmaceutical composition has the effects of warming yang andqi of heart and kidney, eliminating pathogens from lung and inducing diuresis, the clinical and animal tests prove that the pharmaceutical composition can effectively improve the retention of sodium and water of the patients with the heart failure, liver congestion and even liver cirrhosis due to the congestion; at the same time, the pharmaceutical composition has significant protective effect ofthe damaged function of the skeletal muscle during the heart failure. The pharmaceutical composition is applicable to the patients with the heart failure and the different degrees of fluid retention.The pharmaceutical composition can improve the quality of lives of the patients with the chronic heart failure, further improve the exercise tolerance, increase the 6-minute walking distance and improve the function of the skeletal muscle during the heart failure.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for simultaneously improving skeletal muscle function in chronic heart failure and delaying the worsening process of chronic heart failure and a preparation method thereof. Background technique [0002] Due to the increasing incidence of major diseases such as coronary heart disease and hypertension that lead to chronic heart insufficiency and the early arrival of the aging population, heart failure has become the most important heart disease in this century. Chronic heart failure (CHF) is a complex clinical syndrome and the final outcome of various heart diseases. With the prolongation of life expectancy, the prevalence rate of CHF is also increasing year by year. According to statistics, the prevalence rate of adults aged 25-75 may be about 2-3%, while that of people over 65 years old can reach 4-6%. The one-year and five-year survival rat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/16A61P9/04A61P19/08
Inventor 蒋梅先徐燕阮小芬姚成增吴大正
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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