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Method of diagnosing small cell lung cancer

A small cell lung cancer, cell technology, applied in biochemical equipment and methods, microbial assay/test, antitumor drugs, etc., can solve problems such as improper secretion and lack of understanding of the molecular characteristics of neuroendocrine tumors

Inactive Publication Date: 2008-10-08
ONCOTHERAPY SCI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Specific paraneoplastic syndromes, such as inappropriate secretion of antidiuretic hormone, ectopic Cushing's syndrome, and Eaton-Lambert syndrome have been specifically associated with SCLC, but so far The detailed molecular characterization of neuroendocrine tumors is not well understood

Method used

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  • Method of diagnosing small cell lung cancer
  • Method of diagnosing small cell lung cancer
  • Method of diagnosing small cell lung cancer

Examples

Experimental program
Comparison scheme
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Embodiment

[0260] Materials and Methods

[0261] Cell line

[0262] The human SCLC cell line used in this embodiment was as follows: DMS114, DMS273, SBC-3, SBC-5, NCI-H196 and NCI-H446. All cells were cultured in a suitable medium added 10% fetal bovine serum (FCS), and at 37 ° C, in 5% CO 2 The wet air is maintained in the atmosphere of the air.

[0263] Patient and tissue sample

[0264] The late SCLC tissue sample (IV period) is obtained by a Post-Mortem Material (15 individual) in the case of informed constant. This study and all the use of all clinical materials were recognized by the ethics committees of their respective institutions. All cancer tissues were confirmed by pathologists as SCLCs in histological sense. Patient profiles are obtained from medical records. The pathological phase is determined according to the classification of Union InternationalE Contre Le Cancer (Travis WD et al., World Health ORGANIZATION INTERNATIONAL HISTOLOGICAL CLASSIFICATION OF Tumours1999). The cli...

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Abstract

Objective methods for detecting and diagnosing small cell lung cancer (SCLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of an SCLC-associated gene that discriminates between SCLC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of an SCLC-associated gene that distinguishes two major histological types of lung cancer, non-small cell lung cancer (NSCLC) and SCLC. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of small cell lung cancer, methods of treating small cell lung cancer and method for vaccinating a subject against small cell lung cancer. Furthermore, the present invention provides chemotherapy resistant lung cancer- or SCLC-associated genes as diagnostic markers and / or molecular targets for therapeutic agent for these cancers. These genes are up-regulated in chemoresistant lung cancer or SCLC. Accordingly, chemoresistant lung cancer or SCLC can be predicted using expression level of the genes as diagnostic markers. As the result, any adverse effects caused by ineffective chemotherapy can be avoided, and more suitable and effective therapeutic strategy can be selected.

Description

[0001] Cross-reference [0002] This application requires US temporary applications No. 60 / 703, 192 (27 July 2005) and the rights of 60 / 799, 961 (May 11, 2006). All of the contents of the present application are incorporated into these applications for all purposes. Technical field [0003] The present invention relates to methods of detecting, diagnosing, and providing prognosis of small cell lung cancer, further involving methods of treating and preventing cell lung cancer. Background technique [0004] Lung cancer is one of the most common fatal tumors of humans. Many genetic changes associated with the occurrence and development of lung cancer have been reported, but its exact molecular mechanism is still unclear (Sozzi, (2001) EUR JCANCER.; 37 SUPPL 7: S63-73). Small cell lung cancer (SCLC) accounted for 15 to 20% in all lung cancer (Chute JP et al., (1999) J clin oncol .; 17: 1794-801, Simon Gr et al., (2003) CHEST.; 123 ( 1 SUPPL): 259S-271S). Although many patients have go...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11C12N15/113
CPCC12N15/1135C12N2310/14C12Q1/6886C12Q2600/136A61P35/00A61P35/02
Inventor 中村佑辅醍醐弥太郎中鹤修一
Owner ONCOTHERAPY SCI INC
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