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Method for preparing dropping pill using cool air and equipment using the method

A technology of cooling air and dropping pills, which is applied in the direction of making medicines into special physical or taking form devices, dividing liquids into beads and granules, etc., which can solve the problem that the equipment cannot be completely cleaned, organic residues, and coolant residues cannot be solved. and other problems, to achieve the effect of no cleaning dead corners, conducive to stability, and beneficial products

Active Publication Date: 2008-10-08
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dropping pills made by cooling with oil-soluble solvents, cooling liquid residue is an unavoidable problem
Subsequent oil throwing and oil wiping processes are indispensable, but they cannot solve the problem of organic residues; at the same time, due to the adhesiveness of silicone oil and other cooling fluids, the equipment cannot be completely cleaned, which becomes a hidden danger of cross-contamination, which is a problem faced by GMP companies today

Method used

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  • Method for preparing dropping pill using cool air and equipment using the method
  • Method for preparing dropping pill using cool air and equipment using the method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0050] Example 1 prepares compound salvia miltiorrhiza dripping pills:

[0051] Get 600g of Danshen Sanqi extract, 5g of borneol, and 2000g of PEG-6000 auxiliary material. First add PEG-6000 into the chemical tank, heat it to 90°C, melt it in advance, then add the extract of Danshen notoginseng, mix well to form a liquid. Adjust the vibration frequency of the pneumatic vibrating dripper to 50Hz. The heat preservation room adopts a steam jacket for heat preservation, and the temperature is controlled at 80°C. The air pump sends air to the chemical tank through the pipeline, so that the above-mentioned liquid that has been melted evenly flows into the dripper and flows from the dripper. The bottom drips into the cooling pipe, and the cooling pipe is perpendicular to the ground; start the cold air to make the cooling temperature reach -20°C, the angle between the cooling air inlet and the horizontal plane is 45°, and make the cold air circulate in the cooling pipe, so that the dr...

example 2

[0052] Example 2 prepares Danshen dripping pills:

[0053] Take 600g of salvia miltiorrhiza extract, add 60g of water, add 1500g of PEG-6000 auxiliary material, put it into a chemical tank and heat to 90°C, make it completely melt and mix to form a liquid. Adjust the vibration frequency of the pneumatic vibrating dripper to 20Hz. The heat preservation room adopts infrared heating and heat preservation, and the temperature is controlled at 80°C. The air pump sends air to the chemical tank through the pipeline, so that the above liquid that has been melted evenly flows into the dripper and flows from the bottom of the dripper. Drop out into the cooling pipe; start the cold air while the above liquid is dripping out, make the cooling temperature reach -10°C, and make the cold air circulate in the cooling pipe, the angle between the cooling air inlet and the horizontal plane is 45°, so that the dripping The drops of medicine dripped from the head are cooled and solidified into sol...

example 3

[0054] Example 3 prepares Huoxiangzhengqi dripping pills:

[0055] Take Huoxiangzhengqi Extract 200g, Patchouli Oil 1ml, Perilla Leaf Oil 2ml, Polyethylene Glycol 600g, add it into the chemical tank at the same time, heat to 65-85°C, melt, mix evenly to form a liquid. Adjust the vibration frequency of the electric vibrating dripper to 200Hz. The heat preservation room adopts an electric heating jacket to keep warm. The bottom of the head drips into the straight cooling pipe; start the cold air at the same time as the above liquid drips out, so that the cooling temperature reaches -20°C, the angle between the cooling air inlet and the horizontal plane is 90°, and the cold air circulates in the cooling pipe , so that the drops of medicine dripped from the dripper are cooled and solidified in the cooling pipe to form solid pills, and then flow into the collection bucket from the outlet at the lower end of the cooling pipe.

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Abstract

The invention relates to a method for preparing pills by using an air coolant and a device using the method, wherein, the method includes the following steps: heating drugs and accessories in a melting can to be an even liquid, transferring the even liquid to a dripper arranged in a heat preserving chamber, dripping the mixed liquid from the dripper into a cooling duct, starting a refrigerating mode at the same time when the liquid drips so as to maintain the air in the cooling duct at a temperature that the drug drops can be solidified, so that the drug liquid can be cooled and solidified into solid particles in the cooling duct and be dropped into a collecting vessel through an outlet at the lower end of the cooling duct. The device comprises a pill device, a cooling duct hermetically communicated with the pill device and a gas refrigeration device communicated with the cooling duct and circularly conveying cooling air to the cooling duct. The method can avoid the subsequent residual solution process in the traditional condensing way by adopting liquids like whiteruss, silicone oil and so on, having no organic solvent residual and reducing the cost for preparing the pills. The device is characterized by having no dead angle for cleaning, being convenient for cleaning and being able to avoid the cross contamination in the production process, which is beneficial for the stability of the product.

Description

technical field [0001] The invention relates to a pharmaceutical method and equipment thereof. In particular, it relates to a method for preparing dripping pills with cooling air and equipment using the method, which has simple preparation process, no organic residue problem, no hidden danger of cross-contamination, and is easy to clean. Background technique [0002] The preparation of traditional dripping pills is obtained by dropping the melted material into a liquid lysozyme immiscible with the material. The cooled lysozyme can be a water-soluble solvent or an oil-soluble solvent. Among them, water-soluble solvents are mostly water, glycerin, etc.; oil-soluble solvents are mostly paraffin oil and silicone oil. Adopt oil-soluble solvent to cool the dripping pill that makes, and the problem that cooling liquid remains is unavoidable. Subsequent oil throwing and oil wiping processes are indispensable, but they cannot solve the problem of organic residues. At the same time,...

Claims

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Application Information

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IPC IPC(8): B01J2/04A61J3/06
Inventor 孙小兵张文生荣昌盛王世庆章顺楠刘军
Owner TIANJIN TASLY PHARMA CO LTD
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