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Preparation of walnut shell extract and applications thereof in preparations of cardiotonic medicine and cardio-cerebrovascular medicine

A technology of walnut shell and extract, which is applied in the extraction of natural pharmacological active ingredients and its drug preparations for the prevention and treatment of heart and cardiovascular and cerebrovascular diseases, the extraction and preparation of natural walnut shell active ingredients, the preparation of cardiac and the improvement of myocardial ischemia and heart disease. The application field of pharmaceutical preparations for the prevention and treatment of cerebrovascular diseases can solve problems such as easy to cause poisoning, narrow treatment range, and potential safety hazards

Inactive Publication Date: 2008-10-01
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The natural cardiotonic drugs clinically used to treat heart failure are mainly digitalis drugs (such as digoxin) and are widely used, but these drugs are very toxic and have a narrow therapeutic range. The effective dose is close to the toxic dose, and it is easy to Cause poisoning incidents, causing hidden dangers to the safety of medication, and patients cannot use it in large quantities for a long time

Method used

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  • Preparation of walnut shell extract and applications thereof in preparations of cardiotonic medicine and cardio-cerebrovascular medicine
  • Preparation of walnut shell extract and applications thereof in preparations of cardiotonic medicine and cardio-cerebrovascular medicine
  • Preparation of walnut shell extract and applications thereof in preparations of cardiotonic medicine and cardio-cerebrovascular medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] 1.500g of walnut shells were crushed through a 20-mesh sieve, and 1200-1500ml of 70% ethanol was added to reflux for extraction 4 times, each time refluxing for 1 hour. The combined ethanol solution was rotary evaporated, the ethanol was recovered at 60°C, transferred to an oven at 60°C for drying, and 32.6 g of brown-red extract was obtained, with an extraction rate of 6.5%.

[0073] 2. 2000g of walnut shells, crushed through a 20-mesh sieve, added 10000-12000ml of absolute ethanol to reflux for extraction 4 times, each time for 1 hour. The combined ethanol solution was rotary evaporated, the ethanol was recovered at 60°C, transferred to an oven at 60°C for drying, and 120.5 g of brown-red extract was obtained, with an extraction rate of 6.1%.

[0074] 3. 2000g of walnut shells were crushed through a 20-mesh sieve, and 10000-12000ml of 95% ethanol was added to reflux for extraction three times, each time for 1 hour. The residue was refluxed with 10000ml of distilled w...

Embodiment 2

[0076] Take 500g of walnut shell extract, 300g of medicinal starch, 300g of dextrin, and an appropriate amount of 50% ethanol, stir and mix the above-mentioned raw materials to make granules, dry at 60-70°C for 2-4 hours, press into 10,000 tablets, and coat them with sugar. Each tablet contains 0.05g of walnut shell extract.

Embodiment 3

[0078] Take 500g of walnut shell extract, 500g of medicinal starch, and an appropriate amount of 50% ethanol, granulate, granulate, dry, and pack 2# capsules, each 0.1g.

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Abstract

The invention discloses a preparation method for extracting ethanol from an extract of a natural walnut shell, a pharmaceutical composition using the extract as the active component and research results of relevant pharmacology. A walnut shell is ground and boiled for extracting the ethanol and then is concentrated and dried for obtaining the brown red extract. The extracting method is characterized by short process, relatively high extracting rate and is easy for industrialized production. The discovery of the medical value of the walnut shell and the development of the product can prevent great waste of natural pharmaceutical resources. The research of the pharmacological activity shows that the walnut shell extract has a certain activity for strengthening heart and improving myocardial blood supply and is possible to be developed into a new pharmaceutical of natural traditional Chinese medicine for curing cardio-cerebrovascular disease, having a plurality of pharmacological activities, low toxicity and high efficiency. Various oral preparations of different pharmaceutical compositions can be prepared by mixing the extract of effective curing amount with pharmaceutical adjuvant.

Description

1. Technical field: [0001] The invention belongs to the field of medicine, especially the extraction of natural pharmacological active ingredients in the field of natural medicines and its application in drug preparations for preventing and treating heart and cardiovascular and cerebrovascular diseases. The invention relates to a method for extracting and preparing active ingredients from natural walnut shells, more specifically, extracting active ingredients from walnut leftover walnut shells with water or a certain concentration of ethanol, the active ingredients are rich in walnut quinone, its Glycosides, tannins, polysaccharides and vegetable protein components. The invention discloses its extraction and preparation method, a pharmaceutical composition with the extract as an active ingredient, and the application of the composition in the preparation of pharmaceutical preparations for strengthening the heart, improving myocardial ischemia, and preventing and treating cardi...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61P9/00A61P9/10A61K131/00
Inventor 周则卫赵专友沈秀王维亭刘厚孝王晓雪何小云于冰鲁卓林
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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