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A process for extracting total flavonoids from water chestnut skin

A technology of water chestnut skin and total flavonoids, applied in the field of extraction technology of flavonoids, can solve the problems that have not been widely used, and achieve the effect of expanding raw material resources

Inactive Publication Date: 2011-12-07
HEZHOU UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Water leaching and supercritical extraction are not widely used due to many limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0017] Take 100g of water chestnut skin dry powder raw material, put it into an extraction tank, add 1000g of 70% edible ethanol, reflux extraction at 50°C for 3h, filter the extract, repeat 3 times, combine the extract, distill the filtrate under reduced pressure, recover ethanol, residue After drying, add water 5 times the amount of the residue to dissolve, wash with petroleum ether 4 times the amount of the residue several times until the petroleum ether phase is colorless, take the water phase and transfer it to a D101 macroporous adsorption resin column at a flow rate of 0.2BV / H , the ratio of raw material to resin amount is 1: 1.5, wash the resin after adsorption with water at a flow rate of 0.2BV / H to colorless, and then use 80% edible ethanol to elute to no flavonoids at a flow rate of 2.0BV / H Outflow (with FeCl 3 The solution detects the elution of flavonoids, if there are flavonoids, add FeCl 3 When the solution is yellow, if there is no color change), the eluate is...

Embodiment approach 2

[0019] Take 100g of water chestnut skin dry powder raw material, put it into an extraction tank, add 1200g of 60% edible ethanol, reflux extraction at 60°C for 2h, filter the extract, repeat 3 times, combine the extract, distill the filtrate under reduced pressure, recover ethanol, residue After drying, add water 4 times the amount of the residue to dissolve, wash with petroleum ether 3 times the amount of the residue several times until the petroleum ether phase is colorless, take the water phase and transfer it to a D201 macroporous adsorption resin column at a flow rate of 0.5BV / H , the ratio of the raw material to the amount of resin is 1:2, wash the adsorbed resin with water at a flow rate of 0.5BV / H to colorless, and then use 75% edible ethanol to elute with a flow rate of 1.5BV / H until no flavonoids Outflow (with FeCl 3 The solution detects the elution of flavonoids, if there are flavonoids, add FeCl 3 When the solution is yellow, if there is no discoloration), the elu...

Embodiment approach 3

[0021] Take 100g of water chestnut skin dry powder raw material, put it into the extraction tank, add 1500g of 50% edible ethanol, reflux extraction at 70°C for 3h, filter the extract, repeat 2 times, combine the extract, distill the filtrate under reduced pressure, recover ethanol, residue After drying, add 7 times the amount of residue in water to dissolve, wash several times with chloroform that is 6 times the amount of residue, until the chloroform phase is colorless, take the water phase and transfer it to D101 macropore adsorption at a flow rate of 0.8BV / H Resin column, the ratio of raw material and resin amount is 1: 3, the resin after the adsorption is washed with water at the flow rate of 0.8BV / H to colorless, and then with the concentration of 75% edible ethanol with the flow rate of 1.0BV / H Elution to No flavonoids elute (with FeCl 3 The solution detects the elution of flavonoids, if there are flavonoids, add FeCl 3 When the solution is yellow, if there is no color...

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Abstract

A process for extracting total flavonoids from water chestnut skin, which belongs to the technical field of natural medicinal chemistry, is characterized in that water chestnut skin is used as a raw material, and edible ethanol solution is used as a solvent for reflux extraction at 50-70°C, and the extract is degreased and used Macroporous adsorption resin is enriched, and eluted with edible ethanol until no flavonoids flow out (detected with FeCl3 solution), the eluate is concentrated (recovering ethanol at the same time), and dried to obtain the crude product of total flavonoids in water chestnut skin. Extract, then filter, concentrate (recover ethanol at the same time), and dry to obtain refined water chestnut skin total flavonoids. The present invention successfully extracts the total flavonoids of water chestnut skin from water chestnut skin with a yield of 0.8% to 1.2%, is easy to industrialized production, expands the raw material resources of flavonoid products, and turns water chestnut skin, which has always been a waste, into treasure. The flavonoids are green natural products and can be used in the pharmaceutical or food industry.

Description

1. Technical field [0001] The invention relates to a process for extracting flavonoids, belonging to the technical field of natural medicinal chemistry, in particular to a process for extracting total flavonoids from water chestnut skin. 2. Technical background [0002] Water chestnut (Eleochairis toberosa), also known as Water chestnut, is the underground corm of water chestnut, a perennial aquatic herb of Cyperaceae. It is cultivated in all provinces south of the Yangtze River Basin in China, and the output of water chestnut in Guangxi accounts for more than 70% of China's . Water chestnuts are not only juicy, sweet and nutritious, but also have certain medicinal value. It is an excellent fruit and vegetable food with both medicine and food. It has been known as "Jiangnan ginseng" since ancient times. Traditional Chinese medicine believes that water chestnuts are cold in nature and sweet in taste, have the effects of clearing away heat, reducing phlegm, and eliminating ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/89A61P31/04A61P31/12A61K125/00
Inventor 罗杨合解庆林谢复青韦飞梅
Owner HEZHOU UNIV
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