'Zishuiqinggan'oral preparation and preparation thereof
An oral preparation and liver-clearing technology, applied in the field of medicine, can solve problems such as inaccurate dosage, large dosage of traditional Chinese medicine decoction, and inability to commercialize
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Embodiment 1
[0049] Example 1: Preparation method of "Zi Shui Qing Gan" extract 1 (extract and volatile oil)
[0050] Prescription: Rehmannia glutinosa 15g, angelica 9g, white peony 10g, jujube kernel 10g, cornus 10g, poria cocos 9g, yam 12g, Bupleurum 9g, mountain gardenia 9g, paeonol 9g, Alisma 9g.
[0051] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 6-15 times the amount of water to soak for 2-10 hours, heat and boil for 2-3 times, combine the extracts, collect volatile oil; water extraction The liquid was left to stand for 12-48 hours, filtered to get the supernatant, concentrated under reduced pressure to obtain a medicinal extract of about 22.2 g of water extract and about 0.03 g of volatile oil.
Embodiment 2
[0052] Example 2: Preparation method of "Zi Shui Qing Gan" extract 2 (dry powder and volatile oil)
[0053] Prescription: Rehmannia glutinosa 15g, angelica 9g, white peony 12g, jujube kernel 9g, cornus 9g, poria cocos 9g, yam 12g, bupleurum 9g, mountain gardenia 9g, paeonol 9g, alisma 9g.
[0054] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 8-10 times the amount of water to soak for 2-8 hours, heat to boiling and extract 2-3 times, combine the extracts, collect volatile oil; water extraction The liquid was left to stand for 12-48 hours, filtered to take the supernatant, concentrated under reduced pressure, and spray-dried to obtain a dry powder of about 24.2g of water extract; about 0.03g of volatile oil.
Embodiment 3
[0055] Embodiment 3: Preparation method of oral solid preparation of "Zi Shui Qing Gan"
[0056] (1) Preparation of "Zi Shui Qing Gan" Granules
[0057] prescription:
[0058] "Zi Shui Qing Gan" Extract 1 10-90%
[0059] Starch 5.0-70%
[0060] Dextrin 2.0-20%
[0061] Xylitol 5.0-20%
[0062] Methyl sorbate 0.001-2.0%
[0063] Preferred Prescription:
[0064] "Zi Shui Qing Gan" Extract 1 22.2g
[0065] Starch 10.0g
[0066] Dextrin 3.0g
[0067] Xylitol 2.0g
[0068] Methyl sorbate 0.002g
[0069] Preparation method: Prepare the extract of "Zi Shui Qing Gan" according to the method in Example 1, add the prescribed amount of auxiliary materials to make granules according to the conventional method, dissolve the volatile oil with an appropriate amount of ethanol, spray evenly on the granules, dry at low temperature, pack and make Into three bags, each bag 10.1g.
[0070] (2) Preparation of "Zi Shui Qing Gan" tablet:
[0071] (1) Ordinary tablet prescription:
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