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Use of Momordica.charantia seed oil riacylglycerol in preparing medicament for inhibiting tumor cell

A technology of triglycerides and tumor cells, which can be applied in the direction of antineoplastic drugs, drug combinations, and pharmaceutical formulations, and can solve problems such as the inability to explain the structure of TG

Inactive Publication Date: 2008-08-13
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

13 C-NMR method and pancreatic lipase directional hydrolysis TG method are commonly used methods to study the composition and structure of TG, which can understand the information of fatty acid distribution in oil TG as a whole, but still cannot explain the specific structure of TG; in recent years, APCI- The report of the specific TG structure deduced by MS method

Method used

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  • Use of Momordica.charantia seed oil riacylglycerol in preparing medicament for inhibiting tumor cell
  • Use of Momordica.charantia seed oil riacylglycerol in preparing medicament for inhibiting tumor cell

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Effect of Example 1 Test Sample on Human Liver Normal Cell L02 Survival Rate

[0085] The 6 peak samples listed in Table 5 above and the mixed TG sample are a total of 7 samples to be tested and α-caryoic acid samples, which are respectively prepared into sample solutions with a concentration of 25, 50, 100, 200 and 400 μmol / L with the medium, Those who added culture medium but did not add drugs were used as controls, and each sample to be tested had a control to treat normal liver cells L02. After 72 h of culture, the cell viability was detected by SRB method. The experimental results are shown in Table 6.

[0086] Table 6 Different concentrations of grape seed oil TG and isolates

[0087] Effects on the Survival Rate of Normal Liver Cells L02

[0088] group

sample concentration

(μmol / L)

72(h)

survival rate

(%)

group

sample concentration

(μmol / L)

72(h)...

Embodiment 2

[0093] Embodiment 2: Effect of test sample on survival rate of human esophageal cancer cell ECA-109

[0094] The 5 peak samples listed in Table 5 above and the mixed TG sample are a total of 6 samples to be tested and α-caryoic acid samples, which are respectively prepared into sample solutions with a concentration of 31.25, 62.5, 125, 250 and 500 μmol / L with the medium, Those who only added culture medium and no drugs were used as controls, and each sample to be tested had a control, which was used to treat esophageal cancer cells ECA-109. After 72 h of culture, the cell viability was detected by SRB method. The experimental results are shown in Table 7.

[0095] Table 7 Different concentrations of grape seed oil TG and isolates

[0096] Effects on Survival Rate of Esophageal Cancer Cell ECA-109

[0097] group

sample concentration

(μmol / L)

72(h)

survival rate

(%)

gr...

Embodiment 3

[0101] Example 3: Effects of Test Samples on the Survival Rate of Human Gastric Cancer Cell SGC-7901

[0102] The 6 peak samples listed in Table 5 above and the mixed TG sample are 7 samples to be tested and α-caryoic acid samples, which are prepared into sample solutions with concentrations of 31.25, 62.5, 125, 250 and 500 μmol / L with culture medium respectively. The person who only added the culture medium and no drug was used as a control, and each sample to be tested had a control to treat gastric cancer cell SGC-7901. After 72 h of culture, the cell viability was detected by SRB method. The experimental results are shown in Table 8.

[0103] Table 8 Different concentrations of grape seed oil TG and isolates

[0104] Effects on the Survival Rate of Gastric Cancer Cell SGC-7901

[0105] group

sample concentration

(μmol / L)

72(h)

survival rate

(%)

group

sample concentr...

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Abstract

The invention relates to a usage of the scabies grape-kernel oil tri-acylglycerol during the process of preparing a medicine used for suppressing tumour cells. Besides the toxicity of the carcinoma of colon clone is not as good as alpha-eleostearic acid, the tri-acylglycerol containing conjugate linolenic acid in the scabies grape-kernel oil has quite strong toxicity to the four body tumor clones; while although the tri-acylglycerol has not a high toxicity to the normal liver cell, but the intensity is not high. So the scabies grape-kernel oil tri-acylglycerol has good prospect to suppress the colon cell tumor cells.

Description

【Technical field】 [0001] The present invention relates to the use of grape seed extract, more specifically, the present invention relates to the use of grape seed oil triglyceride in the preparation of medicines for inhibiting tumor cells. 【Background technique】 [0002] Momordica charantia L.Var.abbreviata Ser., MCV is a variety of bitter melon, native to eastern India, domesticated and improved by Jiangsu Quality Product Development Service Center, and successfully cultivated by Wuxi Furen Biotechnology Co., Ltd. Large-scale cultivation and development. The fruit of the grape is spindle-shaped as a whole, with irregular spikes on the fruit surface, about 4-10cm long, 3-6cm wide, and 25g-30g in weight. The immature fruit is light green and golden yellow when mature. The appearance of leprosy grape is slightly different from the common bitter gourd in our country. [0003] The oil content in grape seed is about 30%, and the fatty acid composition is relatively simple. The ...

Claims

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Application Information

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IPC IPC(8): A61K31/232A61P35/00A61K36/42
Inventor 汤坚傅伟昌顾小红徐春燕
Owner JIANGNAN UNIV
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