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Saururus loureiri extract and preparation technique thereof

A technology for extracting and extracting liquid of S. chinensis, which is applied in the field of preparation of active ingredients of natural medicines and achieves the effects of good color, strong water solubility and high flavonoid content.

Inactive Publication Date: 2008-08-06
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Systematic research on the enrichment of total flavonoids of Sanbaicao has not yet been prepared, which also limits the further development and utilization of the value of Sanbaicao medicinal materials. Therefore, it is very necessary to provide an extract with a higher content of total flavonoids of Sanbaicao

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 10kg of dried Sanbaicao, crush them, and reflux extract with 10 times the amount of 50% ethanol for 3 times, each time for 1.5 hours, filter, combine the extracts, concentrate under reduced pressure until each ml of the liquid contains about 1g of raw medicinal materials, and the liquid ethanol The content is 15%, put it in a cold place for 24 hours, precipitate fat-soluble impurities such as chlorophyll, filter, take the filtrate, extract the filtrate with n-hexane until the color of the extract becomes light, and then extract it with ethyl acetate until the color of the ethyl acetate liquid becomes light, Discard the n-hexane and ethyl acetate extract, evaporate the organic solvent from the extracted liquid under reduced pressure, continue to concentrate until the relative density is about 1.20, add ethanol and stir to make the ethanol concentration of the liquid 60%, and place it at room temperature for 24 hours. Filtrate, take the filtrate, rinse the filter resi...

Embodiment 2

[0021] Take 10kg of dried Sanbaicao, crush them, and reflux extract with 8 times the amount of 80% ethanol for 3 times, each time for 1.5 hours, filter, combine the extracts, and concentrate under reduced pressure until each milliliter of the liquid contains about 0.8g of raw medicinal materials. The ethanol content is 10%, and it is placed in a cold place for 48 hours to precipitate fat-soluble impurities such as chlorophyll, filter, take the filtrate, extract the filtrate with n-hexane until the color of the extract becomes light, and then extract it with ethyl acetate until the color of the ethyl acetate liquid becomes light , discard the n-hexane and ethyl acetate extract, evaporate the organic solvent from the extracted medicinal solution under reduced pressure, continue to concentrate until the relative density is about 1.20, add ethanol and stir to make the medicinal solution ethanol concentration 70%, and place it at room temperature for 24 hours , filter, take the filt...

Embodiment 3

[0023] Take 10kg of dried Sanbaicao, pulverize it, and extract 3 times with 10 times the amount of 60% ethanol under reflux, each time for 1.5 hours, filter, combine the extracts, concentrate under reduced pressure until each milliliter of the liquid contains about 0.9g of raw medicinal materials, and the liquid The content of ethanol is 20%, put it in a cold place for 24 hours, precipitate fat-soluble impurities such as chlorophyll, filter, take the filtrate, extract the filtrate with n-hexane until the color of the extract becomes light, and then extract it with ethyl acetate until the color of the ethyl acetate liquid becomes light , discard the n-hexane and ethyl acetate extract, evaporate the organic solvent from the extracted medicinal solution under reduced pressure, continue to concentrate until the relative density is about 1.15, add ethanol and stir to make the medicinal solution ethanol concentration 60%, and place it at room temperature for 24 hours , filter, take t...

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Abstract

The invention relates to a Saururus chinensis extract and a preparation method thereof. The Saururus chinensis extract has higher flavone content, which can reach as high as 50 percent above. The Saururus chinensis is extracted in a polar organic solvent, the extraction steps are as follows: dechlorophyllization, low polarity fatty solubility impurity removing, alcohol precipitation to remove amylase and inorganic salt, etc., water-soluble ingredients, adsorbing the extract with an adsorption resin to acquire flavone ingredients full of phenolic hydroxyl. The final extract is light yellow in color and of good water solubility, which is suitable for preparing all kinds of required medicine preparations.

Description

technical field [0001] The invention relates to an active ingredient of botanical medicine, an extract of three white grasses and a method for preparing the three white grass extracts, and belongs to the field of preparation of active ingredients of natural medicines. Background technique [0002] Saururus Chinensis (Lour.)baill is a perennial herbaceous plant of the family Salicaceae. The whole herb is used as medicine, which has the effects of clearing away heat and detoxification, diuresis and swelling. Mainly distributed in the south-central and southwest regions of my country, it can be harvested in all seasons and is rich in resources. Sanbai Cao contains a variety of biologically active ingredients, which have been isolated from volatile oils, flavonoids, lignin, alkaloids, tannins, polysaccharides, etc., and these ingredients have been found to have anti-inflammatory, detoxification, and hypoglycemic properties. , liver protection, diuretic and other activities. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61P3/10A61P3/06
Inventor 张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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