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Uses of tandospirone and derivative thereof in improving memory and cognitive uses

A technology of tandospirone and cognitive function, applied in the field of medicine

Active Publication Date: 2008-07-23
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also no literature report on memory loss caused by neurasthenia, senile dementia, or treatment of senile dementia.

Method used

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  • Uses of tandospirone and derivative thereof in improving memory and cognitive uses
  • Uses of tandospirone and derivative thereof in improving memory and cognitive uses
  • Uses of tandospirone and derivative thereof in improving memory and cognitive uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 The preparation of medicine of the present invention

[0036] Tandospirone 0.007mol (1000 capsules or 1000 tablets)

[0037] Starch 200g

[0038] Microcrystalline Cellulose 5g

[0039] Tandospirone and starch are uniformly mixed by an equal increase method, then mixed with microcrystalline cellulose, granulated, and compressed into tablets to obtain tablets; or packed into capsules to obtain capsules.

Embodiment 2

[0040] The preparation of embodiment 2 medicines of the present invention

[0041] Tandospirone Hydrochloride 0.157mol (1000 pellets)

[0042] Flavor 1.5g

[0043] Distilled water 500ml

[0044] Starch 80g

[0045] Dextrin 20g

[0046] Tandospirone hydrochloride and starch are uniformly mixed by the equal-volume increasing method, then mixed with dextrin and flavoring agent, and then dried into pellets.

Embodiment 3

[0047] Embodiment 3 preparation of medicine of the present invention

[0048] Tandospirone Citrate 0.026mol (1000 capsules or 1000 tablets)

[0049] Starch 80g

[0050] Microcrystalline Cellulose 20g

[0051] Tandospirone citrate and starch are uniformly mixed by an equal increase method, then mixed with microcrystalline cellulose, granulated, and compressed into tablets to obtain tablets; or packed into capsules to obtain capsules.

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PUM

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Abstract

The invention provides the usage of tandospirone and derivatives thereof in the preparation of drugs for improving memory capability and recognition function. The invention also provides a drug combination for improving memory capability and recognition function. The tandospirone and the derivatives thereof can improve memory capability and recognition function and in particular has evident medical treatment effect on poor memory due to neurasthenia or senile dementia. The medicine of the invention can also treat neurasthenia and senile dementia; proved by clinical experiments, the medical effect is remarkable.

Description

technical field [0001] The invention relates to a new application of tandospirone and its derivatives in improving memory and cognitive function and a composition thereof, which belongs to the field of medicine. Background technique [0002] Memory is the function of information stored in the brain or experience reproduction, including four processes of memorization, preservation, recall, and recognition. There are many reasons for memory loss, such as schizophrenia, neurasthenia, senile dementia, mania, obsessive-compulsive disorder, and organic brain lesions. Although the above syndromes all show symptoms of low memory and cognitive impairment, because the etiology of various syndromes is different, the treatment rules for the same symptom caused by various etiologies are different clinically. [0003] Schizophrenia (schizophrenia) is a group of mental illnesses of unknown etiology, mostly onset in young and middle-aged adults, clinically manifested as obstacles in thinki...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61P25/28
Inventor 陈刚陈功政吴建容
Owner SICHUAN CREDIT PHARMA
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