Method for micro-wounded dynamically and continuously detecting blood sugar concentration of human body

Abstract

A minimally invasive, dynamic and continuous detection method for human blood glucose concentration, including: firstly, using low-frequency ultrasound for the pretreatment on skin; secondly, extracting human tissue fluid from the skin after the low-frequency ultrasound pretreatment under the vacuum negative function; thirdly, detecting the skin impedance / resistance during the permeable skin tissue liquid extraction process; fourthly, measuring the glucose concentration of the extracted human tissue liquid; fifthly, using the skin impedance / resistance to determine the extracted tissue liquid volume and to establish the prediction model of the correlation between the glucose concentration in the tissue liquid and the glucose concentration in blood; sixthly, obtaining the human blood glucose concentration according to the skin impedance / resistance that is measured in the third step, the glucose concentration of the human tissue liquid that is measured in the fourth step and the prediction model that is established in the fifth step. The invention can realize the minimally invasive, dynamic and continuous detection method for the human blood glucose concentration and has the advantages of high measurement resolution and precision, good stability of the measured result, small tissue liquid amount to be measured, rapid measuring speed, etc.

Description

technical field [0001] The invention relates to a method for detecting the blood glucose concentration of a human body. In particular, it relates to a minimally invasive, dynamic and continuous detection method of human blood glucose concentration based on low-frequency ultrasonic skin antireflection technology, vacuum negative pressure extraction technology, skin impedance / resistance measurement technology and surface plasmon resonance measurement technology. Background technique [0002] Diabetes is a common and frequently-occurring disease among middle-aged and elderly people. With the improvement of people's living standards, the incidence of diabetes is also increasing. The World Health Organization lists it as one of the three most difficult diseases in the world, along with tumors and cardiovascular and cerebrovascular diseases. . According to the estimates of the International Diabetes Federation, there are currently more than 240 million diabetic patients in the wo...

AI Technical Summary

Problems solved by technology

[0008] Another technical problem to be solved by the present invention is to provide a method of diluting the tissue fluid with a buffer and detecting it using a high-sensitivity surface plasmon resonance protein binding measurement technology to solve the problem that the volume of tissue fluid obtained during each extraction process is very small. Minimally invasive, dynamic, continuous detection method for human blood glucose concentration of glucose concentration in interstitial fluid

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