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Biomarkers for psychotic disorders

A biomarker technology for psychiatric disorders, applied in the field of biomarkers for psychiatric disorders, can solve the problem of less research

Inactive Publication Date: 2008-06-25
PSYNOVA NEUROTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a large number of disease studies have been performed on biological fluids such as urine and plasma, relatively few metabolite profiling studies have been performed on CSF for the purpose of disease diagnosis and identification of key metabolites as biomarkers [10-15 ]

Method used

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  • Biomarkers for psychotic disorders
  • Biomarkers for psychotic disorders
  • Biomarkers for psychotic disorders

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Embodiment

[0174] The present invention will be further understood by reference to the examples provided hereinafter.

[0175] Methods and materials

[0176]The ethics committee of the Faculty of Medicine at the University of Cologne reviewed and approved the study protocol and the procedures for sample collection and analysis. All subjects signed written consent. All clinical studies were performed according to the principles described in the Declaration of Helsinki. CSF samples were obtained from patients with paranoid schizophrenia who were diagnosed as first-episode and not receiving drug treatment, or who were diagnosed with short-term psychotic disorder due to the persistence of the disease (DSM-IV 295.30 or 298.8; n=54), and Demographically corresponding healthy volunteer subjects controls (n=70) (Table 1). In addition, samples from patients meeting DSM-IV criteria for schizophrenia (DSM-IV 295.30) and undergoing typical (total n=6: haloperidol n=4, perazine n=1, fluorine perp...

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Abstract

The invention relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarker(s) present in a cerebrospinal fluid sampie taken from a test subject, said biomarker(s) being selected from the group consisting of: glucose, lactate, acetate species and pH. The invention also relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test sample of CSF from the subject, performing spectral analysis on said CSF test sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to sensors, biosensors, muiti-analyte panels, arrays, assays and kits for performing methods of the invention.

Description

technical field [0001] The present invention relates to methods of using biomarkers to diagnose or monitor psychotic disorders, particularly schizophrenic and bipolar disorders. The biomarkers and methods of using the biomarkers can be used to aid in diagnosis and can be used to assess the onset and progression of psychotic disorders. The present invention also relates to the use of biomarkers in clinical screening, prognosis evaluation, therapy evaluation and drug screening and drug development. Background technique [0002] Diagnosis of existing psychiatric disorders such as schizophrenia and bipolar disorder remains subjective, not only because of the complex range of symptoms and their similarities to other psychiatric disorders, but also because of the lack of empirical disease markers . There is a great clinical need for diagnostic tests and more effective drugs for the treatment of severe mental illness. [0003] Psychosis is a symptom of a serious mental illness. ...

Claims

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Application Information

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IPC IPC(8): G01R33/465
Inventor S・巴恩黄自建曾子文
Owner PSYNOVA NEUROTECH LTD
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