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Substance extracted from giant knotweed for diabetes mellitus and complication thereof

A technology for diabetes and complications, which is applied in the field of substances for the treatment of diabetes and complications, and can solve the problems of unclear hypoglycemic active sites and active ingredients

Inactive Publication Date: 2008-06-25
苗明三
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on its hypoglycemic effect is still limited to water decoction, and its hypoglycemic active parts and active ingredients have not been clarified. The research on its hypoglycemic mechanism is still limited to the overall level. The main chemical constituents - anthraquinones, which are used to treat diabetes and its complications, have not been reported so far

Method used

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  • Substance extracted from giant knotweed for diabetes mellitus and complication thereof
  • Substance extracted from giant knotweed for diabetes mellitus and complication thereof

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Embodiment Construction

[0011] According to the foregoing technical solutions, the present invention is implemented in the following specific manners in implementation.

[0012] The rhizomes and roots of Polygonum cuspidatum are removed from the soil, washed, and crushed into coarse powder (50-80 mesh). Take 1000 grams of coarse powder, add 6000ml of 70% ethanol and soak for 30 minutes, reflux and extract for 2 hours, filter, Obtain the medicinal solution for use, add 6000ml of ethanol with a mass concentration of 70% to the medicinal residue, extract at reflux for 2h, filter, combine the filtrate twice, recover the ethanol under reduced pressure, and concentrate to 50% of the volume, then add the pretreatment and regenerated macropores In the adsorption resin column (the pretreatment and regeneration of the macroporous adsorption resin column are the same as before), elute with distilled water until the eluent is colorless, and then elute with ethanol with a mass concentration of 70%, and collect the el...

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PUM

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Abstract

The invention relates to a substance which is extracted from giant knotweed for curing diabetes mellitus and complicating diseases. By using the substance extracted from the giant knotweed, the medicine for curing diabetes mellitus and the complicating diseases can be produced effectively, and the treatment problems of diabetes mellitus and the complicating diseases are solved. The substance is coarse powder of the giant knotweed and can be prepared through the following steps: putting the giant knotweed in a round flask, adding 6 times quantity of grain alcohol to soak the giant knotweed; refluxing and extracting and filtering the grain alcohol, and the reflux extraction and the filtering are carried out to medical slag which is added with the grain alcohol which is 6 times of the medical slag. The filtrate water are combined for two times, the filtrate water is decompressed for recycling the grain alcohol, and the filtrate water is added in the pretreatment and reborn macro pore adsorption resin column; the resin column is elutriated with distilled water until the eluate is colorless, and the resin column is elutriated with the grain alcohol, the mass concentration of which is 70 percent, the eluate is collected till the eluate does not contain any component of anthraquinone, and the grain alcohol is recycled, and the total anthraquinone which is the extracted substance of the giant knotweed can be gained when the eluate is volatilized on the water bath. The invention has the advantages that the preparation method of the product is scientific, the operation is easy, the quality of the total anthraquinone which is the preparation substance is good, the purity quotient is high and the effect is good. The substance can be used for preparing the medicine which is used for curing diabetes mellitus and the complicating diseases, and the substance which benefits mankind is a creative of the development and the application of the giant knotweed medicine.

Description

1. Technical Field [0001] The invention relates to the field of medicine, in particular to a substance extracted from Polygonum cuspidatum for treating diabetes and complications. 2. Background technology [0002] Diabetes mellitus and its complications (diabetes mellitus, DM) belong to the category of "diminish thirst" in Chinese medicine. It is a disease characterized by polydipsia, polyphagia, polyuria, weight loss, or muddy urine and sweet urine. Modern medicine believes that diabetes is a chronic metabolic disease caused by a variety of causes. It is due to lack of insulin in the body or increased hormones that antagonize insulin, or the inability of insulin to exert normal physiological functions in target cells, causing glucose, protein and lipid metabolism disorders Syndrome. Clinically, it is divided into two types: insulin-dependent diabetes mellitus (IDDM), type I and non-insulin-dependent diabetes mellitus (NIDDM), type II. At present, there are about 157 million diab...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P3/10A61K125/00
Inventor 苗明三
Owner 苗明三
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