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Medicament for treating angina

An angina pectoris and drug technology, applied in the field of drugs for the treatment of angina pectoris, can solve the problems of long treatment cycle, toxic and side effects, and achieve the effects of fast transdermal absorption, stable drug properties and stable properties

Inactive Publication Date: 2008-06-18
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, oral preparations are mostly used in the treatment of angina pectoris, and no external preparations have been seen. Oral administration has a long treatment cycle and relatively large toxic and side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the medicine for the treatment of angina pectoris (trade name: angina pectoris ointment)

[0033] prescription:

[0034] Astragalus 300g Angelica 120g Paeoniae Alba 120g Chuanxiong 90g Habitat 150g Radix Glycyrrhiza 60g;

[0035] Preparation:

[0036] A. Extraction process

[0037] (a) Take angelica and other six herbs, decoct twice with water, first use 8 times the amount of water, decoct for 2 hours, and second time use 6 times the amount of water, decoct for 2 hours, filter, combine the filtrate, reduce Concentrate under pressure to a relative density of 1.25, leave to cool at room temperature, add ethanol to make the alcohol content 70%, stir well, let stand for 12 hours to precipitate, take the supernatant to recover ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.40 , vacuum-dried at 65°C to obtain a dried product, pulverized, and passed through a 100-mesh sieve,

[0038] (b) taking the above-mentioned me...

Embodiment 2

[0042] Embodiment 2: the medicine for the treatment of angina pectoris (trade name: angina pectoris cataplasm)

[0043] prescription:

[0044] Astragalus 300g Angelica 120g Paeoniae Alba 120g Chuanxiong 90g Habitat 150g Radix Glycyrrhiza 60g;

[0045] Preparation:

[0046] A. Extraction process:

[0047] (a) Take angelica and other six herbs, decoct twice with water, first use 8 times the amount of water, decoct for 2 hours, and second time use 6 times the amount of water, decoct for 2 hours, filter, combine the filtrate, reduce Concentrate under pressure to a relative density of 1.25, leave to cool at room temperature, add ethanol to make the alcohol content 70%, stir well, let stand for 12 hours to precipitate, take the supernatant to recover ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.40 , vacuum-dried at 65°C to obtain a dried product, pulverized, and passed through a 100-mesh sieve;

[0048] (b) Get the above-mentioned med...

Embodiment 3

[0052] Embodiment 3: the medicine ointment stability investigation for the treatment of angina pectoris

[0053]According to the "Technical Requirements for New Drug Research of Traditional Chinese Medicine" promulgated and implemented by the State Drug Administration, the technical requirements for quality stability research of new traditional Chinese medicines are stipulated. The ointment and cataplasm for treating angina pectoris were made according to the established process, and the properties, moisture retention, content and microbiological inspection items were observed at room temperature. The results show that all the control indicators meet the national ointment quality standards, and the quality is stable after being placed at room temperature for six months.

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PUM

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Abstract

The invention discloses a drug for treating angina pectoris, which is a compound paster for external application finely made from six medicinal herbs: astragalus, angelica sinensis, white peony root, ligusticum wallichii, radix rehmanniae and mix-fried licorice as effective components through process of water extracting-alcohol precipitating and has the effect of blood-activating and stasis-dissolving, Qi promoting and pain relieving and obvious angina pectoris curing. The ointment body of the paster is fine and smooth, easy to be coated without melting and small volume to facilitate using and carrying and favorable for quick recovery of lesions and has the advantages of stable medicine properties of the soft paster, quick percutaneous absorption, good ventilation capability and gradual drug delivery. Compared with orally taken formulas, the invention has the advantages of no enterohepatic first-passing function, no affect by gastrointestinal degradation and high degree of biological utilization; compared with injections, the invention has the advantages of convenient using and no pain; compared with pastes, the invention has the advantages of accurate dosage of administration and fixed absorption area; compared with black plasters and adhesive plasters, the invention has the advantages of no skin allergy nor clothes pollution, long acting, percutaneous absorption and convenient carrying and using.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a medicine for treating angina pectoris. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, the Ministry of Health standard WS 2 -B-0928-91 records the prescription: [0003] Peach kernel (fried) 200g Angelica 150g Citrus aurantium (bran fried) 100g Chuanxiong 75g Bupleurum 50g [0004] Safflower 150g Achyranthes bidentata 150g Radix Paeoniae Rubra 100g Rehmannia glutinosa 150g Bellflower 75g Licorice 50g [0005] Functions and indications: promoting blood circulation and removing blood stasis, promoting qi and relieving pain. Used for blood stasis internal resistance, chest pain or headache, internal heat and depression, insomnia and dreaminess, palpitations, irritability and anger. [0006] Preparation Process: [0007] Grind 100g of peach kernels, angelica, red peony root, citrus aurantii, Chuanxiong, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/70A61K47/42A61P9/10
Inventor 李建民高惠明
Owner TIANJIN ZHONGBAO PHARMACY
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