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Antidepressive Chinese medicine composition and method of preparing the same

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve problems such as effective treatment of unfavorable depression, lack of Chinese patent medicine for depression, etc.

Inactive Publication Date: 2008-06-11
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Now antidepressants include monoamine oxidase (MAO) inhibitors, tricyclic drugs (TCA), tetracyclic drugs and third-generation antidepressants (5-HT reuptake inhibitors, etc.) according to the discovery time, but there are differences The degree of side effects is not conducive to the effective treatment of depression
Since ancient times, my country's traditional Chinese medicine has accumulated rich experience in the prevention and treatment of depression, but the current pharmaceutical market still lacks effective Chinese patent medicines for the treatment of depression.

Method used

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  • Antidepressive Chinese medicine composition and method of preparing the same

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Embodiment 1

[0032] The preparation of embodiment 1 granule

[0033] Weigh each raw material according to the following weight (unit: g): Astragalus 200, Bupleurum 100, Cimicifuga 100, Cornus officinalis 150, Albizia Julibrissin 200, Morinda officinalis 100, Shichangpu 100, Coptis 30;

[0034] Astragalus is decocted twice with 8 times the weight of water, decocting for 1 hour each time, filtering, combining the filtrate, and concentrating it to a relative density of 1.25-1.30 (55°C) to obtain a concentrated solution of Astragalus, which is set aside; Hemp, Cornus officinalis, Albizia Julibrissin, Morinda officinalis, Shichangpu, and Coptis chinensis are decocted twice with 8 times the weight of water, decocting for 1 hour each time, filtering, combining the filtrates, and concentrating the filtrates to a relative density of about 1.08-1.10 (55°C ), to obtain a mixed concentrated solution, add ethanol to the mixed concentrated solution until the alcohol concentration is 80%, refrigerate for...

Embodiment 2

[0035] The preparation of embodiment 2 tablet

[0036] Weigh each raw material according to the following weight (unit: g): Astragalus 100, Bupleurum 50, Cimicifuga 50, Cornus officinalis 100, Albizia juniper 100, Morinda officinalis 50, Shichangpu 50, Coptis 20;

[0037]Astragalus is decocted with 6 times the weight of water for 4 times, decocting for 0.5 hours each time, filtering, combining the filtrate, and concentrating it to a relative density of 1.25-1.30 (55°C) to obtain a concentrated solution of Astragalus, which is set aside; Hemp, Cornus officinalis, Albizia Julibrissin, Morinda officinalis, Shichangpu, and Coptis chinensis are decocted with 6 times the weight of water for 4 times, each decocting for 0.5 hours, filtered, and the filtrates are combined, and the filtrate is concentrated to a relative density of about 1.08-1.10 (55°C ), to obtain a mixed and concentrated extract; add ethanol to the mixed concentrate to adjust the alcohol concentration to 50%, refriger...

Embodiment 3

[0038] The preparation of embodiment 3 capsules

[0039] Weigh each raw material according to the following weight (unit: g): Astragalus 300, Bupleurum 150, Cimicifuga 150, Cornus officinalis 200, Albizia Julibrissin 300, Morinda officinalis 150, Shichangpu 150, Coptis 60;

[0040] Astragalus is decocted with 10 times the weight of water for 3 hours, and the filtrate is concentrated to a relative density of 1.25-1.30 (55°C) to obtain a concentrated solution of Astragalus, which is used for later use; Decoct Coptis chinensis with 10 times the weight of water for 3 hours, filter, and concentrate the filtrate to a relative density of about 1.08-1.10 (55°C) to obtain a mixed concentrate; add ethanol to the mixed concentrate to adjust the alcohol concentration to 90%, and refrigerate After 24 hours, filter, after the ethanol is recovered from the filtrate under reduced pressure, add the astragalus water extract and continue to concentrate under reduced pressure to a clear paste wit...

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Abstract

The invention discloses a traditional Chinese medicine composition of antidepressants and process for preparation. The invention is constituted by raw materials with following parts by weight: astragalus root 10-30 parts, radix bupleuri 5-15 parts, cimicifuga foetida 5-15 parts, cornus officinalis 10-20 parts, albizia bark 10-30 parts, morinda root 5-15 parts, acorus gramineus soland 5-15 parts and coptis root 2-6 parts. The medicament of the invention can be processed to oral preparation which is suitable for clinic according to the traditional Chinese conventional pharmaceutical method. The invention has the functions of nourishing liver, eliminating phlegm and relieving depression, which can effectively cure depression, asthenia, and forgettery with depressive symptoms and physical signs such as hypodynamia, habitual sigh, abdominal distension, dim complexion, corpulent tongue with thin and greasy fur, thin pulse string and the like, the curative effect is distinctive, the clinical application is safe, and no side effect is found.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an antidepressant traditional Chinese medicine composition and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] With the progress of society and the development of economy, the material living standards of human beings have been greatly improved, but it is also accompanied by considerable mental pressure, resulting in depression, self-blame, boredom, loss, irritability, depression, tension and emotional stress. Mental disorder. These are increasingly perplexing the lives of modern people. The World Health Report 2001 published by the World Health Organization emphasizes that depression has become the fourth largest disease in the world. October 10th of each year has been designated as "World Mental Health Day". It can be seen that depression has become one of the serious disease factors affecting social developme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P25/24
Inventor 李林魏海峰赵玲王文李雅莉
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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