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Chemical synthesis technique of quinoxaline

A chemical synthesis, quinolone technology, applied in the direction of organic chemistry

Inactive Publication Date: 2008-05-21
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Abstract
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Problems solved by technology

The results show that the antibacterial effect of quinocetone after heavy ion irradiation is significantly improved, and the chemical structure of the monomer monomer of the irradiation product will provide the basis for artificial chemical synthesis, and it may become a method for finding new drugs. There is no report on this aspect of work

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  • Chemical synthesis technique of quinoxaline
  • Chemical synthesis technique of quinoxaline
  • Chemical synthesis technique of quinoxaline

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Embodiment Construction

[0083] The implementation process of three kinds of chemical synthesis techniques of quinolone is described as follows now:

[0084] The synthetic technique of the first kind of operational route:

[0085] (1) Dissolve 18.3g (0.133mol) of o-nitroaniline in 70g of methanol, add 25.3g (0.266mol) of 50% aqueous sodium hydroxide solution, continue stirring at 0-10°C, and slowly add 127g ( 0.185mol) sodium hypochlorite aqueous solution (the available chlorine content is 5.2%), the dropwise addition is completed in about one hour, then continue stirring at 010° C. for 1 hour, and the water phase is separated. The methanol solution of benzofurazan-1-oxide was obtained, washed with water, and filtered to obtain 17.4 g of benzofurazan-1-oxide.

[0086] (2) Dissolve 16.2g of benzofurazan-1-oxide and 13.5g of acetylacetone in 30ml of triethylamine, let the solution stand at room temperature for 18 hours, collect the precipitate, and dry it to obtain 16g The 2-acetyl-2-methylquinoxaline...

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Abstract

The present invention is a chemical synthesis process of quinolone, which relates to the field of veterinary drug feed additives. The existing synthesis technology is to select from various quinoxaline compound substituted derivatives, but these compounds have relatively large toxic and side effects, and simply change The side chain can no longer meet the needs. The present invention uses heavy ion beams to modify the structure of quinoxaline to produce new compound molecules. Through pharmacodynamic research, the standard sample is separated for chemical synthesis. The present invention designs three synthetic routes. Corresponding to the three chemical synthesis processes, the new compound was identified by spectrum, and it was determined to be quinolone. After further growth-promoting and toxicity tests, it showed obvious improvement and improvement compared with the lead compound quinolone. The invention has the beneficial effects of greatly shortening the development cycle and greatly saving the development cost, and shows that quinolone is a very vital veterinary drug feed additive.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a veterinary medicine feed additive. Background technique [0002] In terms of drug transformation and development, since Haddalin and Issidorides of Beirut, Lebanon published the first article on the Beirut reaction in 1965, hundreds of patents using this reaction have been published and no less than a thousand new N, N -Diazapine-1,4 dioxide (quinoxaline) compounds. In fact, substituted derivatives of various quinoxaline compounds synthesized according to the Beirut reaction, such as Catbadox, Quinocetone, Mequin, etc., are used as antibacterial and growth-promoting agents in animal husbandry, veterinary medicine and aquaculture. , has achieved huge economic and social benefits. However, such compounds have relatively large toxic and side effects, and simply changing their side chains cannot meet the needs, because the result is often that the toxicity is reduced and the ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D241/52
Inventor 梁剑平卫增泉何荣智王曙阳
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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