Anti Toll-like receptor 2 antibody anti pulmonary fibrosis use

Abstract

The present invention discloses an ant-toll sample receptor 2 antibody. It can obviously reduce the death rate of mice infused by using bleomycin, and can block TLR2 signal channel so as to obviously reduce inflammation and injury of lung induced by bleomycin, can reduce pulmonary fibrosis due to bleomycin and pulmonary oxyproline hydroxyproline content and can reduce expression of TLR2+, so that the anti-Toll sample receptor 2 antibody can be used for preparing medicine for preventing and curing pulmonary fibrosis.

Description

technical field [0001] The invention relates to a new application of an anti-Toll-like receptor 2 antibody in preventing and treating pulmonary fibrosis, and belongs to the technical field of medicine. Background technique [0002] Toll-like receptors (Toll like receptors, TLRs) are newly discovered innate immune receptors, they can recognize pathogenic microorganisms broadly and specifically, couple signal transduction pathways, and activate innate immune cells, eventually leading to a series of immune responses. Inflammation. TLRs can not only activate innate immunity, but also provide co-stimulatory signals for the activation of acquired immunity. TLRs play an important role in innate immunity and acquired immunity, and are the bridge between the two. Generally, TLR4 plays an important role in acute inflammation, while TLR2 plays a key role in chronic inflammation. [0003] Bleomycin (BLM) is a long-acting antineoplastic drug isolated from Streptomyces verticularis, an...

AI Technical Summary

Problems solved by technology

Bleomycin has significant antitumor effects, but it also has significant side effects, including lung inflammation, pulmonary fibrosis, and myelosuppression, which greatly limit its clinical use

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