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Drug eluting stent and therapeutic methods using C-JUN N-terminal kinase inhibitor

A kinase inhibitor and a drug delivery technology are applied in the field of systems and devices for preventing stenosis and restenosis, and can solve the problems of toxic shelf-storage time and limited storage time of anti-proliferative agents.

Inactive Publication Date: 2008-02-27
杨笕春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of the remaining problems with current stents include the toxicity of certain antiproliferative agents and the limited shelf life of these products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] The present invention is based on the discovery that when one or more JNK inhibitors are incorporated into a stent, they can be administered in a via-release manner to patients with vascular trauma such as that which occurs during conventional balloon angioplasty or stent implantation. In mammals, it reduces or eliminates restenosis of injured blood vessels.

[0036] JNK inhibitors can be incorporated into stents using a polymer matrix that can be used to cover the body of the stent, which is the same design as known and used techniques.

[0037] Since the JNK inhibitor used in the present invention includes pyrazolantrone and its derivatives, any polymer or its composition suitable for possessing and releasing this type of substance can be used. Suitable polymers may include hydrophobic polymers or mixtures of polymers or copolymers having certain hydrophobic characteristics. Examples include the pegylated styrenic block copolymer matrices described in US Patent No. 6...

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Abstract

The present invention relates to a system and device for preventing stenosis and / or restenosis after an invasive procedure in a body vessel or cavity having an inner wall surface, the system comprising inserting a device coated with a growth arresting, lipid-derived, bioactive substance at a desired location along the inner wall surface of the body vessel or cavity. The present invention provides for the use of c-Jun aminoterminal kinase inhibitor (''JNK Inhibitor'') and certain analogs as restenosis inhibitors, incorporated into a stent.

Description

【Technical field】 [0001] The present invention relates to systems and devices for preventing stenosis and restenosis of blood vessels or body cavities with inner wall surfaces after invasive treatment. 【Background technique】 [0002] Percutaneous coronary intervention (PCI) is used to treat obstructive coronary artery disease by compressing atheroma to the side of the vessel wall. PCI is widely used and has an initial success rate of over 90%. In 2000 approximately 12 million angioplasty procedures were performed in the United States alone. Although this procedure is frequently used and its initial success rate is high, the long-term success of PCI is limited by intraluminal renarrowing or restenosis at the procedure site. [0003] The American Heart Association also pointed out in its 2006 Heart Disease and Stroke Statistical Report that several major types of cardiovascular procedures and procedures have shown a long-term upward trend. [0004] Vascular restenosis is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61F2/82
CPCA61F2/82A61F2250/0067A61P7/02
Inventor 杨笕春
Owner 杨笕春
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