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Raidx cynanchum bungei decne glycoside of mountain Tai and preparation method thereof

The technology of Baishouwu glycosides granules and Baishouwu can be used in pharmaceutical formulations, medical preparations containing active ingredients, and bulk delivery, etc., and can solve the problems of poor curative effect and low availability of active ingredients in traditional Chinese medicine.

Inactive Publication Date: 2008-02-20
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the deficiencies of the prior art and solve the problems of low availability and poor curative effect of active ingredients in traditional Chinese medicines, the present invention provides a Taishan Baishougluside granule preparation and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] The preparation method of Taishan Radix Baishougluside Granular Preparation of the present invention, the steps are as follows:

[0020] Pass Taishan Radix Polygonum glycosides powder through 80 mesh sieve, weigh Taishan Radix Radix Polygonum glycosides powder, filler and flavoring agent according to the amount, mix them evenly and pass through 100 mesh sieve, add 95% ethanol (bonding agent) to prepare The soft material is granulated, dried at 60-70°C, granulated, and packaged separately to obtain the Taishan Radix Radix Radix Granules.

[0021] For the above methods that are not limited in detail, existing wet granulation and sizing techniques in the art can be used.

[0022] The Taishan Baishougluside granule preparation of the present invention has high bioavailability, has the functions of immune regulation, blood lipid lowering, anti-oxidation, etc., and can be used as an efficient, safe, and convenient health care product or medicine for treating diseases such as ...

Embodiment 1

[0043] Example 1: Extraction of Taishan Radix Radix Polyglucosides

[0044] Take Taishan Baishouwu coarse powder, add 10 times the weight of 95% ethanol, extract three times under reflux in a water bath at 70°C, each time for 2 hours, combine the three filtrates, concentrate under reduced pressure to recover the solvent, concentrate to 5% volume, and obtain the extract for future use. Add a small amount of water to suspend the extract, go through AB-8 macroporous adsorption resin column chromatography, elute with water, and discard the eluent; then elute with 95% ethanol and acetone (the volume ratio of ethanol and acetone is 2:1 ), collect the eluent, recover the solvent under reduced pressure, concentrate to 2% volume to obtain extract, dry in vacuum at 60° C. for 24 hours to obtain dry solid, and pulverize into fine powder to obtain Taishan Radix Polygonum glycosides powder.

Embodiment 2

[0045] Embodiment 2: Taishan Radix Radix Granules Preparation

[0046] The raw material components of Taishan Baishougluin Granules preparation are as follows:

[0047] Taishan Baishouwu Total Glycosides Powder 60g

[0048] Starch 550g

[0049] Microcrystalline Cellulose 200g

[0050] Lactose 150g

[0051] Stevia 1.5g.

[0052] Preparation:

[0053] Pulverize the total glycosides powder of Taishan Radix Polygonum glycosides prepared in Example 1 and pass through an 80-mesh sieve, weigh 60.0 g of total glycosides of Taishan Radix Polygonum glycosides powder, 550 g of starch, 200 g of microcrystalline cellulose, 150 g of lactose, and 1.5 g of stevia , mix evenly, pass through a 100-mesh sieve, add 95% ethanol to make a soft material, granulate, dry at 70°C, granulate, and pack into 1000 bags to obtain Taishan Radix Radix Radix Granules.

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PUM

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Abstract

The present invention relates to a Cynanchum bungei Decne glycoside granular preparation and the preparation method thereof. The components of the preparation are total glycosides of Cynanchum bungei Decne, fillers and flavoring agents. The preparation method is that the purified extract of total glycosides of Cynanchum bungei Decne, fillers and flavoring agents are mixed in proportion and the Cynanchum bungei Decne glycoside granulars are prepared by using the size stabilization process after the wet granulation. The Cynanchum bungei Decne glycoside granular preparation of the present invention has the effects of regulating immune, lowering blood lipid, anti-oxidation and so on, the present invention is characterized by high utilization of the active ingredients, and the present invention can be used in the prevention and the treatment of hyperlipidemia and other diseases.

Description

technical field [0001] The invention relates to a Taishan Baishougluside granule preparation and a preparation method thereof, and belongs to the technical field of granule preparations made from extracts of Chinese medicinal materials and pharmaceutical auxiliary materials. technical background [0002] Dyslipidemia is currently recognized as an extremely important risk factor for atherosclerosis. In recent years, surveys on the blood lipid levels of healthy people in my country have found that the blood total cholesterol and triglyceride levels of both men and women are higher than before, and the risk of atherosclerosis is correspondingly increased. Therefore, how to reduce the risk of atherosclerosis is an important aspect of cardiovascular disease research in my country. [0003] According to statistics, the mortality rate of cardiovascular and cerebrovascular diseases has exceeded 1 / 2 of the total mortality rate of the population. Due to excessive fat deposition, art...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61K9/16A61P3/06A61K125/00
Inventor 秦大伟孟霞李树英段洪东
Owner QILU UNIV OF TECH
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