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Oral insulin enteric capsule and its preparation method

A technology of enteric-coated capsules and insulin, applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2008-02-20
司炳奎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral insulin preparations become a gap in clinical practice

Method used

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Embodiment Construction

[0005] The invention is an oral insulin enteric-coated capsule. The raw material is insulin powder: 10 units per capsule; the auxiliary material is medicinal starch: 0.09 grams of starch granules and 0.01 grams of starch per capsule; the capsules are common enteric-coated capsules. The preparation method of this medicine is: 1, raw material adopts insulin powder: each capsule 10 units; Adjuvant medicine adopts medical starch: each capsule 0.09 gram of starch granules, 0.01 gram of starch, capsule adopts common enteric-coated capsule, and medicinal Put the starch in a mixer, use the starch slurry to make a soft material, use a 20-mesh nylon sieve to granulate, use a 18-mesh sieve to granulate after drying, transfer to the mixing workshop to cool, sieve out fine powder, and use the remaining starch granules for later use; 2 1. Fully mix the sieved fine powder and insulin fine powder according to the incremental method and then fully mix with the starch granules produced in step 1...

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Abstract

The present invention relates to an oral insulin enteric-coated capsule and the preparation method, the raw materials use the insulin powder: each capsule has 10 units; excipients adopt medical starch: each capsule has 0.09g of starch granules and 0.01g of starch, the capsule adopts the common enteric-coated capsule, the medical starch is placed in a mixer, the starch paste is prepared into the soft material, a 20 mesh nylon screen is used for granulation, a 18 mesh screen is used for size stabilization after drying, then the starch is transferred into a mixing department for cooling, fine powder is screened out, and the remaining starch granules are ready for use; 2. the screened fine powder and the insulin fine powder are mixed fully and mixed evenly according to the incremental method and then are fully mixed with the starch granules which are produced in step 1; 3. the powder is transferred to a capsule filling department, an automatic capsule filling machine is used for filling; 4. the capsule after the filling is transferred to an aluminum foil packaging department for packaging after the polishing; 5. the capsule is transferred into a packaging room for packaging after the aluminum foil and then is transferred to a refrigerator chamber after completion. The present invention applies the oral insulin enteric-coated capsule for treating diabetes, the cost is low, the efficacy is good, the administration is easy, and the patients can avoid the suffering of the injection.

Description

Technical field: [0001] The invention relates to an oral insulin enteric-coated capsule and a preparation method thereof. Background technique: [0002] At present, the incidence of diabetes in my country and the world is on the rise, especially the complications caused by diabetes, which seriously threaten human health. Oral insulin preparations have not been clinically used so far. The patient only used hypoglycemic drugs: glyburide tablets and phenformin tablets. The bitter gourd capsules and propolis capsules that have been on the market in recent years have been called "plant insulin". However, the only way the body regulates blood sugar is insulin. Hypoglycemic drugs, or "plant insulins" are no substitute for real insulin. Taking hypoglycemic drugs for a long time, there is a problem of drug resistance, and it will cause damage to the liver and kidneys. Some patients have no choice but to use insulin injections when their condition worsens. It is very inconvenien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K38/28A61P5/48
Inventor 司炳奎
Owner 司炳奎
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