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Preparations containing rosuvastatin calcium and amlodipine and method for preparing the same

A technology of rosuvastatin calcium and amlodipine is applied to the preparation field containing rosuvastatin calcium and amlodipine and the preparation field thereof to achieve the effect of synergistic effect

Inactive Publication Date: 2008-01-02
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also no relevant literature reporting literature on the combination of the two

Method used

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  • Preparations containing rosuvastatin calcium and amlodipine and method for preparing the same
  • Preparations containing rosuvastatin calcium and amlodipine and method for preparing the same

Examples

Experimental program
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Effect test

Embodiment 1

[0066] Prescription (each tablet contains 5 mg rosuvastatin calcium: 5 mg amlodipine)

[0067] Rosuvastatin Calcium 50g

[0068] Amlodipine 50g

[0069] Starch 1500 2325g

[0070] Sodium carboxymethyl starch 2.5g

[0071] Magnesium Stearate 1.25g

[0072] Micronized silica gel 1.25g

[0073] Povidone 2.5g

[0074] Take the prescribed amount of rosuvastatin calcium and amlodipine, and mix them with the prescribed amount of starch 1500 and sodium carboxymethyl starch by using the equal amount incremental method. Gained mixture uses recipe quantity povidone solution as binding agent wet granulation (boiling granulation granulator FL3-C, Shanghai Far East Pharmaceutical Machinery Factory). The obtained wet granules were sized after drying at 55°C. Add the prescribed amount of magnesium stearate and micropowder silica gel to the granules after granulation, and then tablet (rotary tablet press ZP-19, Shanghai No. 1 Pharmaceutical Machinery Factory) to get 10,000 tablets. The...

Embodiment 2

[0076] Prescription (7.5 mg rosuvastatin calcium per tablet: 5 mg amlodipine)

[0077] Rosuvastatin Calcium 75g

[0078] Amlodipine 50g

[0079] Microcrystalline Cellulose 375g

[0080] Sucrose 750g

[0081] Calcium phosphate 1125g

[0082] Povidone 37.5g

[0083] Crospovidone 62.5g

[0084] Talc powder 25g

[0085] Take the prescribed amount of rosuvastatin calcium and amlodipine, and mix them with the prescribed amount of microcrystalline cellulose, powdered sugar (powder after crushing sucrose), calcium phosphate, and crospovidone by equal addition method. Gained mixture uses recipe quantity povidone solution as binding agent wet granulation (boiling granulation granulator FL3-C, Shanghai Far East Pharmaceutical Machinery Factory). The obtained wet granules were sized after drying at 55°C. Add the prescribed amount of talcum powder to the granules after granulation, and then compress 10,000 tablets (rotary tablet press ZP-19, Shanghai No. 1 Pharmaceutical Machinery ...

Embodiment 3

[0087] Prescription (each tablet contains 9.0 mg rosuvastatin calcium: 5 mg amlodipine)

[0088] Rosuvastatin Calcium 90g

[0089] Amlodipine 50g

[0090] Microcrystalline Cellulose 375g

[0091] Starch 735g

[0092] Calcium phosphate 1125g

[0093] Povidone 37.5g

[0094] Crospovidone 62.5g

[0095] Talc powder 25g

[0096] Take the prescribed amount of rosuvastatin calcium and amlodipine, and mix them with the prescribed amount of microcrystalline cellulose, starch, calcium phosphate, and crospovidone using the equal-volume incremental method. Gained mixture uses recipe quantity povidone solution as binding agent wet granulation (boiling granulation granulator FL3-C, Shanghai Far East Pharmaceutical Machinery Factory). The obtained wet granules were sized after drying at 55°C. Add the prescribed amount of talcum powder to the granules after granulation, and then compress 10,000 tablets (rotary tablet press ZP-19, Shanghai No. 1 Pharmaceutical Machinery Factory). Gai...

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Abstract

The invention provides a medical compound, which comprises effective amount of rosuvastatin calcium and amlodipine, which is characterized in that said two material are combined together and they can reduce blood fat and blood pressure, and they are cooperative.

Description

technical field [0001] The invention relates to a medicine for treating hyperlipidemia, hypercholesterolemia and antihypertension and a preparation method thereof, in particular to a preparation containing rosuvastatin calcium and amlodipine and a preparation method thereof. Background technique [0002] Rosuvastatin calcium is an HMG-CoA reductase inhibitor, which can be used to treat atherosclerosis, hyperlipidemia, familial hypercholesterolemia and similar diseases. The molecular formula of rosuvastatin calcium is as follows: [0003] [0004] Rosuvastatin calcium is a calcium salt formed by basification of a single enantiomer (3R, 5S) carboxylic acid. The dihydroxyheptenoic acid part of the molecule is the common pharmacophore of statins, and the rest is different from other The presence of a polar methanesulfonyl amino group makes it relatively less lipophilic. The hydrophilicity of rosuvastatin calcium means that its passive diffusion ability is low, so it is diff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/505A61K31/4422A61K9/00A61P3/06A61P9/12
Inventor 高原陈彬华郑启兰夏凌云李玉柱曾亚琳
Owner SHANGHAI SINE PHARMA LAB
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