Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
一种胃泌素释放肽、炎性疾病的技术,应用在脓毒症和急性肺损伤,双相性精神障碍领域
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[0108] I)
[0109] Here, the inventors of the present invention demonstrate the therapeutic potential of the bombesin / GRP antagonist RC-3095 for the treatment of the inflammatory disease rheumatoid arthritis.
[0110] They further demonstrated the therapeutic potential of the bombesin / GRP antagonist RC-3095 for the treatment of two inflammatory diseases, sepsis and acute lung injury. Experiments on the effect of RC-3095 on macrophages revealed that RC-3095 impairs the release of pro-inflammatory cytokines TNF-α and IL-1β by activated macrophages.
[0111] In a well-established model of experimental sepsis, treatment with the bombesin / GRP receptor antagonist RC-3095 attenuated TNF-α and Serum levels of IL-1β and increase survival in inflammatory diseases, especially in "established" sepsis. Furthermore, the bombesin / GRP antagonist RC-3095 was found to reduce lung injury induced by intratracheal instillation of lipopolysaccharide (LPS) in an established acute lung injury (ALI)...
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