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Traditional Chinese medicine containing red sage root and its preparation

A technology of composition and traditional Chinese medicine, which is applied in the field of pharmaceutical composition and preparations for treating cardiovascular diseases, and can solve problems such as difficult preparation of dripping pills

Active Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The raw materials are 495g of Salvia miltiorrhiza, 118g of ginseng and 4.5g of balsamic oil.

[0067] Salvia miltiorrhiza and ginseng were decocted in 5 times the amount of water, decocted for 2 hours, filtered, and the filter residue was extracted for the second time, added 4 times the amount of water, decocted for 1 hour, filtered, the filter residue was discarded, and the filtrate was combined. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. Add balsamic oil, dry, make granules, compress into tablets, or coat with sugar, that is to say.

Embodiment 2

[0069] Danshen 490g, Styrax 4g.

[0070] Salvia miltiorrhiza is extracted with 70% ethanol, and the extract is micro-filtered with a ceramic membrane to collect the filtrate; the filtrate is ultra-filtered, and the operating conditions of the ultra-filtration process are: the pressure of the liquid inlet of the ultra-filtration is 0.35Mpa, and the pressure ratio of the liquid outlet of the ultra-filtration is 0.35Mpa. The inlet pressure is 0.20kPa lower. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m / s. Nitrogen is intermittently fed into the ultrafiltration ...

Embodiment 3

[0073] Raw material Danshen 485g, angelica 100g, borneol 2.2g.

[0074] Add 5 times the amount of water to Danshen and Angelica, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. The extract and borneol are fluidized with lactose in a batch fluidized bed, dried, and made into granules.

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular disease. The composition is mainly prepared from Salvia miltiorrhiza, Borneo or Dalbergia odoriferous oil or styrax or musk or musk ketone as raw material; also can further comprises Angelica sinensis or Herba Leonuri or further step comprises Astragalus membranaceus or ginseng or radix codonopsis. Its processing steps comprises preparing Salvia miltiorrhiza into water extract or alcohol extract or preparing Salvia miltiorrhiza and Angelica sinensis or Herba Leonuri or Salvia miltiorrhiza and Astragalus membranaceus or ginseng or radix codonopsis pilosulae into water extract or alcohol extract respectively or together, performing primary clarification, performing ultra filtration treatment, concentrating, and mixing with Borneo or Dalbergia odoriferous oil or styrax or musk or musk ketone. The invention also discloses a preparation with any of the aforesaid Chinese medicinal composition as effective ingredient, preferably dripping pill. Its dripping pill substrate adjuvant can be polyethylene glycol or plant original substrate adjuvant. Inventive medicament has rapid action, and good therapeutic action in treating angina pectoris of coronary heart disease.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular diseases and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases which is made from traditional Chinese medicinal materials. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in my country, and rose to second and third respectively after 1970. Cardiovascular and cerebrovascular diseases accounted for the first of all causes of death. In my country, the proportion of deaths due to cardiovascular and cerebrovascular diseases to the total death population has risen from 12.07% in 1957 to 42.6% in 2001, and 2...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122
Inventor 李旭郑永锋白雨
Owner TIANJIN TASLY PHARMA CO LTD
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