Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for extracting penicillin by magnetic ion liquid and reactor

A magnetic ionic liquid, ionic liquid technology, applied in organic chemistry and other directions, can solve the problems of organic solvent loss, environmental pollution, explosion danger, etc., to prevent emulsification, low shear force, and enhance mass transfer.

Inactive Publication Date: 2007-11-14
INST OF PROCESS ENG CHINESE ACAD OF SCI
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are three major disadvantages in this extraction process: it is necessary to add acid to adjust the pH value to denature the protein and cause emulsification of the system; the volatilization of the organic solvent causes environmental pollution, and there is a potential explosion hazard; the loss of the organic solvent and the low yield due to the entrainment of the two phases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extracting penicillin by magnetic ion liquid and reactor
  • Method for extracting penicillin by magnetic ion liquid and reactor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: magnetic ionic liquid [bmim]FeCl 4 The result of extracting penicillin (using a three-blade propeller to stir)

[0040] 15ml of penicillin solution with a penicillin content of 1g / 100ml and 10ml of magnetic ionic liquid [bmim]FeCl 4 mix. Stir with a propeller at a speed of 300 rpm. Slight emulsification phenomenon after 10 minutes, centrifuged for 5 minutes, the extraction system was layered, and the upper aqueous phase and the lower ionic liquid phase were taken respectively. The aqueous phase solution was analyzed by polarimeter for penicillin content, and the ionic liquid phase was analyzed for penicillin content by high-performance liquid chromatography. The extraction rate of penicillin by ionic liquid was 76.65%.

Embodiment 2

[0041] Embodiment 2: magnetic ionic liquid [bmim]FeCl 4 The implementation results of extracting penicillin (using a reactor with rotating and lifting magnetic stirring isolation tank)

[0042] Please refer to Figure 1. An isolation tank 6 is installed in the reactor, and a rotary motor 4 is connected with a shaft 5 in the isolation tank 6. The bearing at one end of the rotary motor 4 is connected with the NdFeB permanent magnet 3, and the upper outer shell of the isolation tank 6 is connected with a sliding shaft. .

[0043] 15ml of penicillin solution with a penicillin content of 1g / 100ml and 10ml of magnetic ionic liquid [bmim]FeCl 4 mix. As shown in Figure 2a, the magnetic ionic liquid and the penicillin solution in the reactor are in a layered state after mixing, the ionic liquid is in the lower layer 1, and the penicillin solution is in the upper layer 2; the upper part is a rotating and lifting magnetic stirring isolation tank; as shown in Figure 2b , turn on the ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention relates to a method of using acidic, magnetic and hydrophobic ion liquid to extract penicillin, and reactor of magnetism whiping disperse system. Massfraction of penicillin in the mixture is 0.5 to 8%. The magnetic and hydrophobic ion liquid submit acidity, and massfraction of the ion liquid is 20 to 60%. The invention adopts [bmim] FeCl4 to extract penicillin, can reach 75% upwards extraction rate without acidification. The invention adopts reactor with gyrating, fluctuating magnetic stirring isolation pot, through outfield strengthening effect to realize intensive mixing and sharp separation of magnetic ion liquid and penicillin water solution; the magnetism of ion liquid realize low shearing whipping, and prevent emulsification in extraction process; the invention has no centrifugalization system after whipping, avoid biphase entrainment of traditional method; the power of this reactor is greatly less than conventional dasher, depress energy expenditure in extraction process.

Description

technical field [0001] The invention relates to a method and a reactor for extracting penicillin with a magnetic ionic liquid, in particular to a method for extracting penicillin with an acidic and magnetically functional hydrophobic ionic liquid, and a reactor for a magnetically stirred dispersion system. technical background [0002] Penicillin is one of the most common antibiotics. Its production process is to extract penicillin from the penicillin filtrate with an organic extraction solvent after the solid-liquid separation of the penicillin fermentation liquid, and then obtain the penicillin product through steps such as back extraction, crystallization and drying. The link of penicillin extraction is to use butyl acetate as the extractant, adding acid to adjust the pH value. This extraction process has three major disadvantages: it is necessary to add acid to adjust the pH value to denature the protein and cause emulsification of the system; the volatilization of the o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D499/18
Inventor 江洋洋郭晨余江刘会洲安震涛
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com