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Method of extracting and refining palmatin hydrochloride and application thereof

A technology of palmatine hydrochloride and refining method, which is applied in the field of medicine and can solve problems affecting the efficacy and safety of drugs

Inactive Publication Date: 2007-10-24
HANGZHOU HAOMAI MEDICINE TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, regardless of the palmatine hydrochloride content of palmatine hydrochloride in the market, regardless of the palmatine hydrochloride tablets, palmatine injections, and palmatine suppositories, they contain many impurities, which affect the efficacy and safety of the medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1) Palmatine hydrochloride extraction

[0051] Grind the medicinal material of the yellow vine, add 10 times the amount of 0.8% to 1.0% dilute sulfuric acid aqueous solution, soak for 48 hours, and filter. Adjust the pH of the filtrate to about 10 with sodium hydroxide, then add industrial sodium chloride according to the weight of 10% of the filtrate volume, stir and dissolve, let it stand for 24 hours, discard the supernatant by siphoning, and centrifuge the lower sediment to obtain Parma hydrochloride. Tin crude (dry weight about 4%).

[0052] The wet crude product is reflux extracted with 12-15 times the amount of 95% ethanol (about 15-30 minutes), filtered while it is hot, concentrated under reduced pressure to about 5 times the crude alkali (V / M), and adjusted to pH 2-3 with concentrated hydrochloric acid. Stand still, cool down, precipitate yellow needle crystals, filter with suction, and dry in the air to obtain palmatine hydrochloride.

[0053] 2) Refining of...

Embodiment 2

[0056] Embodiment 2 preparation of palmatine hydrochloride tablet

[0057] Recipe: Palmatine Hydrochloride 100g

[0058] Microcrystalline Cellulose 20g

[0059] Starch 20g

[0060] 10% ethanol solution of povidone

[0061] Magnesium Stearate Appropriate amount

[0062]Preparation method: Pass 100g of palmatine hydrochloride, 20g of microcrystalline cellulose, and 20g of starch through a 120-mesh sieve, mix uniformly according to the equal-volume incremental method, and make a soft material with an appropriate amount of 10% povidone ethanol solution, granulate, Drying and sizing, mixing the granules with a water content of about 3% and an appropriate amount of magnesium stearate evenly, and pressing them into 1000 tablets according to a conventional method.

[0063] At the same time, the present invention can also be made into small-dose injections, freeze-dried powder injections, large-capacity injections, ordinary tablets, ordinary capsules, soft capsules, pills, micropil...

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PUM

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Abstract

The invention discloses an extracting refining method and drug composition of alcaine palmatine, which adopts alcaine palmatine as raw material to prepare the drug to strengthen the pharmacological action and improve the safety.

Description

technical field [0001] The invention relates to a method for extracting and refining palmatine hydrochloride and an application thereof, belonging to the technical field of medicine. Background technique [0002] Fibrauretin (Fibrauretinum) is an alkaloid extracted from the stem of Fibraurea recisa pierre. It has the function of clearing heat and detoxifying. For gynecological inflammation bacillary dysentery, enteritis, respiratory tract and urinary tract infection, surgical infection, conjunctivitis. Its active ingredient is palmatine hydrochloride, which is the main active ingredient. But at present, regardless of the palmatine hydrochloride content of the palmatine hydrochloride tablets, palmatine injections, and palmatine suppositories sold on the market, they contain more impurities, which affect the efficacy and safety of the medicine. [0003] The invention lies in that after the extraction and refining process is improved, the content of palmatine hydrochloride c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03A61K31/4745A61K36/59A61P31/00A61K125/00
Inventor 陈长潭
Owner HANGZHOU HAOMAI MEDICINE TECH
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