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Composition of medication, preparation method and application

A composition and drug technology, applied in pharmaceutical formulations, drug delivery, antibacterial drugs, etc., can solve the problem that the etiological treatment of viral infectious diseases is rarely used, and achieve the goal of reducing drug resistance, reducing the occurrence, and delaying drug resistance. The effect of the production of medicinal strains

Active Publication Date: 2007-10-10
黄金秀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the wide application of antibacterial drugs, most bacterial diseases have been effectively controlled, but the etiological treatment of viral infectious diseases is still rarely used clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Preparation of Injections

[0077] Take 900 grams of sodium chloride, 20 grams of citric acid, and 30 grams of cysteine ​​hydrochloride, put them in a sterile container, add 30% of the prepared water for injection and stir to dissolve, and adjust the pH value at 6.8 with 1mol / l sodium hydroxide Add 0.10% (g / ml) medicinal charcoal to absorb for 20 minutes, filter and decarbonize to obtain the auxiliary material formulation. Take 80 grams of Yanhuning and 2,000 grams of cephalothin and put them in a sterile container, add 5% water for injection and stir to dissolve, add 0.05% (g / ml) medicinal charcoal to adsorb for 20 minutes, filter and decarbonize, and obtain the main drug Dosing. After mixing the two solutions, add water for injection to 100 liters; after passing the test, fine filter with a φ0.22um microporous membrane, and fill the obtained fine filtrate into 100ml infusion bottles, a total of 1000 bottles, filled with nitrogen, Pressed butyl rubber stopper, rolled...

Embodiment 2

[0079] Take 900 grams of sodium chloride, 30 grams of citric acid, and 50 grams of cysteine ​​hydrochloride, put them in a sterile container, add 30% of the total amount of water for injection, stir and dissolve, and adjust the pH value at 6.8 with 1mol / l sodium hydroxide About, add 0.10% (g / ml) medicinal charcoal to adsorb for 20 minutes, filter and decarbonize. Then take 200 grams of Yanhuning and 2000 grams of cefazolin and put them in a sterile container, add 5% water for injection and stir to dissolve, add 0.05% (g / ml) medicinal charcoal for adsorption for 20 minutes, filter and decarbonize, and Medicine dispensing solution. After mixing the two solutions, add water for injection to 100 liters; after passing the test, fine filter with a φ0.22um microporous membrane, and fill the obtained fine filtrate into 100ml infusion bottles, a total of 1000 bottles, filled with nitrogen, Pressed butyl rubber stopper, rolled aluminum cap; sterilized by autoclaving at 115°C for 30 min...

Embodiment 3

[0081] Preparation of Powder Injection by Freeze-drying Process

[0082] Take 200g Yanhuning, 1000g ceftriaxone sodium, add water for injection to about 1800ml, stir to dissolve, adjust the pH value to 6.0-7.5, add 0.03% (g / ml) of medicinal active carbon, stir for decolorization, filter for decarbonization, Add sterile water for injection to 2000ml, stir well, after passing the test, fine filter with a microporous membrane, and the filtrate is divided into cleaned and sterilized control antibiotic bottles, each bottle is 2ml, a total of 1000 bottles, half-tightened, Put it into a freeze dryer for freeze-drying, stoppering, capping, inspection, and packaging. Each bottle of the finished product contains Yanhuning 0.2g and ceftriaxone sodium 1g. It is used for pneumonia, bronchitis, peritonitis, pleurisy, and infections of skin and soft tissues, urinary tract, biliary tract, bones and joints, facial features, and wounds. 1 bottle at a time, once a day, twice for severe cases. ...

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Abstract

A composite medicine for treating various bacterial and viral infections is prepared from the Yanhuning (dehydroandrographolide0potassium sodium succinate), cephalo- type antibiotics, and medicinal auxiliaries. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition, its preparation method and its application, specifically relate to a kind of pharmaceutical composition composed of Yanhuning, cephalosporin antibiotics and pharmaceutically acceptable adjuvant, its preparation method and its preparation and treatment by Respiratory tract infection, gastrointestinal tract infection, biliary tract infection, urinary tract infection, gynecological infection, ENT infection, skin and soft tissue infection, bone and joint infection and prevention of surgical infection caused by various sensitive viruses and bacteria. Background technique [0002] Yanhuning is dehydroandrographolide potassium half-ester succinate sodium salt, its chemical name is: 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinate half-ester potassium sodium salt, It is a new type of drug that is extracted from traditional Chinese medicine and its active ingredients are semi-syn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61K31/546A61K9/08A61K9/14A61K9/19A61P31/04A61P31/12A61K31/365
Inventor 黄金秀
Owner 黄金秀
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