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Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients

A technology of emulsifiers and preparations, applied in food ingredients, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as low biological activity

Active Publication Date: 2007-08-22
美国分子技术工业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Low bioactivity of lipophilic dietary components with very low water solubility can be a serious problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Ethyl oleate was used to prepare six CoQ10 solution formulations, SF-1 to SF-6, which contained the ingredients shown in Table 1.

[0104] Table 1 Formulation composition (mg / g) of CoQ10 preparation solutions of SF-1 to SF-6

[0105] Ingredients

[0106] Total amount =

Embodiment 2

[0108] ECLA was used to prepare six CoQ10 solution formulations, SF-7 to SF-12, which contained one of the ingredients shown in Table 2.

[0109] Table 2 Formulation composition (mg / g) of CoQ10 preparation solutions from SF-7 to SF-12

[0110] Ingredients

[0111] Total amount =

Embodiment 3

[0113] Six formulations of lycopene solutions, SF-13 to SF-18, were prepared using ethyl oleate or ECLA, which contained the ingredients shown in Table 3.

[0114] Table 3 The formula (mg / g) of the lycopene preparation solutions of SF-13 to SF-18

[0115] Ingredients

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PUM

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Abstract

The present invention provides novel dietary supplement compositions based on the use of a particular oil phase which comprises of Coenzyme Q10 and optionally other lipophilic dietary ingredients of low water solubility and a liquid mixture which comprises one or more emulsifiers, a fatty acid monoester formed between a short chain alcohol of C1 and C4 chain length and a saturated, or mono-unsaturated, or di-unsaturated (both conjugated and non-conjugated) fatty acid of C6 to C24 chain length, or medium chain mono- / di-esters, or the mixture of above. The composition is in a form of self-emulsifiable in the aqueous medium, for example, a simulated gastric fluid, which should provide a high oral bioavailability for the lipophilic dietary ingredients.

Description

[0001] This application claims priority from US Patent No. 60 / 601,070 filed on September 3, 2004. This content is incorporated into this application by reference. [0002] Throughout this application, multiple publications are cited. In order to more fully describe the state of the field to which the present invention belongs, the disclosures of these publications are incorporated into this application by reference in their entirety. Technical field [0003] The present invention relates to liquid formulations suitable for oral administration, especially those that can self-emulsify in an aqueous medium such as simulated gastric juice. Background technique [0004] According to the definition of the DietarySupplement Health and Education Act of the US Congress (http: / / www.fda.gov / opacom / laws / dshea.htm#sec3), the bill was passed in 1994. Food additives It is a kind of (a) used to supplement food; (b) contains one or more food supplement ingredients (including vitamins, minerals, he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/122
CPCA23L1/302A23L1/035A23L1/3002A23L1/3004A23L1/3008A23L1/303A23V2002/00A61K31/122A23L29/10A23L33/105A23L33/11A23L33/12A23L33/15A23L33/155A23V2250/1876A23V2250/1884A23V2250/314
Inventor 吉米·小曾·王
Owner 美国分子技术工业有限公司
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