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Method for Chinese patent drug fast quantitative analysis by acousto-optic filter near infrared spectral technique

A technology of near-infrared spectroscopy and quantitative analysis, which is applied in the field of quantitative analysis of Chinese patent medicines, can solve the problems of inability to realize online rapid quantitative analysis, cumbersome quantitative analysis operations, and long analysis cycle, and achieve the improvement of Chinese patent medicine analysis and detection technology. Analysis of rapid, easy-to-operate effects

Inactive Publication Date: 2007-08-22
山东医学高等专科学校
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Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention utilizes the 5th generation AOTF near-infrared spectrum analyzer to provide a method for rapid quantitative analysis of Chinese patent medicines using the near-infrared spectroscopy technology of acousto-optic tunable filters, which solves the problem of quantitative analysis of Chinese patent medicines. The operation is cumbersome, the analysis period is long, the operation cost is high, and the online rapid quantitative analysis cannot be realized. It provides a new green analysis method for the quantitative analysis in the complex system of Chinese patent medicine.

Method used

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  • Method for Chinese patent drug fast quantitative analysis by acousto-optic filter near infrared spectral technique
  • Method for Chinese patent drug fast quantitative analysis by acousto-optic filter near infrared spectral technique
  • Method for Chinese patent drug fast quantitative analysis by acousto-optic filter near infrared spectral technique

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Embodiment 1

[0032] Acousto-optic tunable filter near-infrared spectroscopy technology for rapid quantitative analysis of Chinese patent medicines, taking Compound Danshen Tablets as an example, the steps are as follows:

[0033] 1) The samples of Compound Danshen Tablets were collected as the calibration set samples for building the model. The calibration set samples were representative, the range of chemical properties covered all possible ranges of the samples to be tested, and the chemical data showed a certain gradient distribution.

[0034] 2) Determination of the content of tanshinone IIA and salvianolic acid B in the collected samples of Compound Danshen Tablets by using the method specified in the 2005 Pharmacopoeia (HPLC), and obtain the reference data of the chemical values ​​of the two indicators.

[0035] 3) Use the AOTF-NIR spectrometer to collect the spectral data of each sample in the calibration set by means of diffuse reflectance.

[0036] 4) Perform spectral processing o...

Embodiment 2

[0041] Acousto-optic tunable filter near-infrared spectroscopy technology for rapid quantitative analysis of Chinese patent medicines, taking Yinhuang oral liquid as an example, the steps are as follows:

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Abstract

A method uses acousto-optic adjustable filter near infrared (AOTF-NIR) spectrum technique in quick qualitative analysis of proprietary Chinese medicine. Near infrared spectrum is combined with medicine informatics by AOTF-NIR spectrum technique and computer etc. NIR spectrum of correcting set samples is collected by AOTF near infrared spectrometer. Physical and chemical data of sample parameters is determined by conventional chemical analyzing apparatus. Based on function relationship formed between them, these spectrum data and parameters are associated by mathematics. Quantitative model is built by least-squares procedure (LSP) to analyze. Based on the invention, quick qualitative analysis for other proprietary Chinese medicine and on-line monitoring method in key segments of proprietary Chinese medicine production are realized, which advances research technique development of proprietary Chinese medicine.

Description

1. Technical field [0001] The invention relates to a method for quantitative analysis of Chinese patent medicines, in particular to a method for rapid quantitative analysis of Chinese patent medicines using near-infrared spectroscopy with an acousto-optic tunable filter. 2. Background technology [0002] At present, there are new research results emerging in the field of near-infrared (NIR) spectral analysis technology at home and abroad, and these results play an important role in industrial production such as food, medicine, and tobacco. NIR spectral analysis technology is a modern high-tech analysis and testing technology. It is an analysis method that uses NIR light to contain rich material information for analysis. It is mainly used for qualitative and quantitative analysis of organic matter. The biggest features are: non-destructive to the sample, easy to operate, rapid analysis, the measurement signal can be transmitted and analyzed over a long distance, especially co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/27G01N21/35G01N33/15G01N21/3563G01N21/3577G01N21/359
Inventor 王宁蔡绍松魏红董海平
Owner 山东医学高等专科学校
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