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Middle gut positioning sausage dissolvable pharmaceutical formulations for relieving diarrhea and processes for their preparation

A colon positioning, astringent intestinal antidiarrheal technology, applied in the direction of drug combination, pharmaceutical formula, pill delivery, etc., can solve the problems of heavy workload of medical staff, poor patient compliance, inconvenient use, etc.

Active Publication Date: 2009-12-09
GUANGDONG BANGMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, enema administration is very painful for patients, and the workload of medical staff is heavy, and it is inconvenient to use, so patients' compliance is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1. Astringent intestinal antidiarrheal colon-positioned enteric-coated tablets

[0046] Tablet core prescription: (1000 tablets)

[0047] Montmorillonite 500.0g

[0048] Yantuo 833.3g

[0049] Starch 10.0g

[0050] Magnesium Stearate 2.5g

[0051] Coating Solution Prescription:

[0052] Polyacrylic resin III 35.0g

[0053] Dibutyl phthalate 3.5g

[0054] Titanium dioxide 8.0g

[0055] Talc powder 8.0g

[0056] 80% ethanol 680g

[0057] Preparation method, the steps are as follows:

[0058] (a) pretreatment of Yantuo medicinal materials;

[0059] Weigh the Yantuo medicinal material and crush it into a coarse powder, soak it three times with 80% ethanol. 4 times the weight of the top, combine the soaking liquid three times, recover the ethanol under reduced pressure and concentrate to the extract with a relative density of 1.10~1.20 / 50~60°C. Add hydrochloric acid to adjust the pH value to 2, let it stand overnight, filter, and concentrate the filtrate ...

Embodiment 2

[0062] Example 2. Astringent intestinal antidiarrheal colon-positioned enteric-coated tablets

[0063] Tablet core prescription: (1000 tablets)

[0064]Montmorillonite 500g

[0065] Yantuo 833.3g

[0066] Sodium carboxymethyl starch 30g

[0067] Magnesium Stearate 2.5g

[0068] Coating Solution Prescription:

[0069] Polyacrylic resin III 50g

[0070] Dibutyl phthalate 16g

[0071] Titanium dioxide 40g

[0072] Talc powder 40g

[0073] 80% ethanol 850g

[0074] The preparation method is the same as that in Example 1, and the weight gain of the coating is 6-10%.

Embodiment 3

[0075] Example 3. Astringent intestinal antidiarrheal colon-positioned enteric-coated tablets

[0076] Tablet core prescription: (1000 tablets)

[0077] Montmorillonite 500g

[0078] Yantuo 833.3g

[0079] Starch 30g

[0080] Magnesium Stearate 3g

[0081] Coating Solution Prescription:

[0082] Polyacrylic resin III 100g

[0083] Dibutyl phthalate 10g

[0084] Titanium dioxide 50g

[0085] Talc powder 50g

[0086] 80% ethanol 850g

[0087] Coating parameters:

[0088] Flow rate of coating solution 2.6ml / min

[0089] Inlet temperature 40℃

[0090] Spray pressure 1.3kgf / cm 2

[0091] The preparation method is the same as that in Example 1, and the weight gain of the coating is 6-10%.

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Abstract

The astringent intestine antidiarrheal colon-targeted enteric-coated pharmaceutical preparation and a preparation method thereof belong to the technical field of colon-targeted enteric-coated pharmaceutical preparations. The active ingredients of the preparation are montmorillonite and rock tuo, which are coated with colic-soluble coating materials so that the drug will not disintegrate and release in the upper gastrointestinal tract; after the preparation reaches the colon, it will disintegrate and release rapidly Drugs, so that the drugs can directly contact with intestinal lesions to improve the curative effect.

Description

technical field [0001] The invention relates to a colon-targeted enteric-coated medicinal preparation, in particular to a colon-targeted enteric-coated medicinal preparation for astringent intestines for antidiarrheal and a preparation method thereof. Background technique [0002] Montmorillonite drug has a lamellar structure and non-uniform charge distribution. It has a fixed inhibitory effect on digestive tract viruses, bacteria and their toxins, and has a strong covering ability on the digestive tract mucosa. Proteins combine with each other to repair both qualitatively and quantitatively, and improve the defense function of the mucosal barrier against attacking factors. The montmorillonite does not enter the blood circulation system, and is excreted together with the fixed attack factor through the peristalsis of the digestive tract itself. The montmorillonite does not affect the X-ray examination, does not change the color of the stool, and does not change the normal in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K33/12A61K9/20A61K9/48A61K47/32A61K47/38A61P1/12
Inventor 陈建明李崇伟刘立平陈晶闫允寿
Owner GUANGDONG BANGMIN PHARMA
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