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Powder injection contg high content tanshin polyphenolic acid salts, and its preparation method

A technology of salvia polyphenolate and polyphenolate, which is applied in the directions of medical preparations containing active ingredients, powder delivery, pharmaceutical formulations, etc., can solve problems such as adverse reactions, occurrences, and incomplete elucidation of the active ingredients of salvia miltiorrhiza

Active Publication Date: 2009-09-09
SHANGHAI GREEN VALLEY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Danshen injection is a commonly used drug for clinical treatment of coronary heart disease, angina pectoris, myocardial infarction, ischemic stroke and other diseases. Appeared, it does not meet the requirements of modernization and internationalization of traditional Chinese medicine
The key to the emergence of these problems is that the active ingredients of Salvia miltiorrhiza have not been fully clarified.

Method used

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  • Powder injection contg high content tanshin polyphenolic acid salts, and its preparation method
  • Powder injection contg high content tanshin polyphenolic acid salts, and its preparation method
  • Powder injection contg high content tanshin polyphenolic acid salts, and its preparation method

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example 1

[0067] After 1 portion of Salvia miltiorrhiza is crushed, it is decocted and extracted three times with 4 times the amount of water, 2 times the amount of water, and 2 times the amount of water, and the extraction time is 2 hours each time. The three extracts were combined, cooled to room temperature, centrifugally filtered, and the filtrate slowly flowed through an adsorption column equipped with 3 times the amount of 1300-I macroporous resin. After the adsorption is complete, wash away sugar, protein and inorganic salts with 6 times the amount of water, then use 6 times the amount of 20% ethanol to remove salvianolate compounds other than Salvia acetic acid salt, and finally wash with 3 times the amount of 50% ethanol Desalvianolate. According to TLC detection, collect 50% ethanol eluate rich in salvia miltiorrhiza, concentrate under reduced pressure to 1 / 10 of the crude drug amount, slowly add 9 / 10 of the crude drug amount of absolute ethanol under stirring, and let it stan...

example 2

[0069] After 1 portion of Salvia miltiorrhiza is crushed, it is decocted and extracted three times with 4 times the amount of water, 2 times the amount of water, and 2 times the amount of water, and the extraction time is 2 hours each time. The three extracts were combined, cooled to room temperature, centrifugally filtered, and the filtrate slowly flowed through an adsorption column equipped with 3 times the amount of D101 macroporous resin. After the adsorption is complete, wash away sugar, protein and inorganic salts with 6 times the amount of water, then use 6 times the amount of 20% ethanol to remove salvianolate compounds other than Salvia acetic acid salt, and finally wash with 3 times the amount of 50% ethanol Desalvianolate. According to TLC detection, collect 50% ethanol eluate rich in salvia miltiorrhiza, concentrate under reduced pressure to 1 / 10 of the crude drug amount, slowly add 9 / 10 of the crude drug amount of absolute ethanol under stirring, and let it stand ...

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Abstract

The invention discloses a high-content salvianolate powder injection. In the powder injection, the magnesium acetate content of salvia miltiorrhiza is 50%-95%, and the content of effective parts of polyphenolate is nearly 100%. Preclinical pharmacology, toxicology and clinical test results show that it is a high-efficiency, low-toxic cardiovascular drug, which is superior to the existing Danshen preparations. The invention also provides a preparation method, which ensures the quality of the preparation, overcomes the shortcomings of the existing Danshen injection, and has great application value.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine. Specifically relates to a high-content salvianolate powder injection and a preparation method thereof. Background technique: [0002] In recent years, the incidence of cardiovascular disease has increased year by year. According to statistics, there are more than 100 million hypertensive patients and more than 10 million coronary heart disease patients in China. Cardiovascular disease has gradually become the "first killer" that endangers people's health. Finding and developing effective therapeutic drugs for cardiovascular diseases has always been the focus in the field of drug research. Traditional Chinese medicine has shown strong advantages in this field, among which Danshen and its preparations are more famous. Salvia miltiorrhiza Bunge is one of the traditional traditional Chinese medicines for promoting blood circulation and removing blood stasis, and has a long-te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/14A61P9/00
Inventor 丁愉刘志安史晓浩刘国平孟庆国吴云鸣陈磊孙溢郁雅萍邓慰慰
Owner SHANGHAI GREEN VALLEY PHARMA
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