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Azithromycin oral disintegration tablet and its preparing method

A technology of oral disintegrating tablets and azithromycin, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problem that the medication needs of all patients cannot be fully met, that it is inconvenient for patients to swallow and take water, and it is difficult for patients to take medicines, and children cannot take medicines by themselves. and other problems to achieve the effect of improving bioavailability, good taste and shortening dissolution time

Active Publication Date: 2009-05-27
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently, the dosage forms of azithromycin in clinical use include ordinary tablets, capsules, suspensions, injections, granules, etc. Most of these oral dosage forms need to be taken with water, and it will be difficult for patients with difficulty in swallowing or taking water; although granules The granule is a dosage form specially designed for children, but because most children cannot drink it by themselves, and it is inconvenient to take granules in schools or kindergartens, these dosage forms cannot fully meet the medication needs of all patients

Method used

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  • Azithromycin oral disintegration tablet and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Preparation of Azithromycin Orally Disintegrating Tablets

[0045] Component Weight Weight %

[0046] Azithromycin 100g 33.3%

[0047] Mannitol 88g 29.3%

[0048] Aspartame 3g 1%

[0049] Menthol 1g 0.4%

[0050] Chocolate Powder Flavor 3g 1%

[0051] appropriate amount of water

[0052] Low Substituted Hydroxypropyl Cellulose 18g 6%

[0053] Microcrystalline Cellulose 72g 24%

[0054] Citric acid 3g 1%

[0055] Sodium bicarbonate 9g 3%

[0056] Magnesium Stearate 3g 1%

[0057] Total weight 300g

[0058] A total of 1000 pieces were made

[0059] Concrete preparation method is as follows:

[0060] Weigh azithromycin, mannitol, aspartame, menthol, and chocolate powder flavors that have passed through a 100-mesh sieve, mix them evenly, add an appropriate amount of aqueous solution to granulate, and weigh the additional excipients low-substituted hydroxypropyl cellulose and microcrystalline fiber according to the prescription Sodium glutamate, citric ...

Embodiment 2

[0061] Example 2: Preparation of Azithromycin Orally Disintegrating Tablets

[0062] Component Weight Weight %

[0063] Azithromycin 100g 25%

[0064] Erythrose 125g 31.25%

[0065] Aspartame 4g 1%

[0066] Menthol 1g 0.25%

[0067] Chocolate Powder Flavor 8g 2%

[0068] 50% ethanol appropriate amount

[0069] Low Substituted Hydroxypropyl Cellulose 32g 8%

[0070] Microcrystalline Cellulose 96g 24%

[0071] Citric acid 6g 1.5%

[0072] Sodium bicarbonate 24g 6%

[0073] Magnesium Stearate 4g 1%

[0074] Total weight 400g

[0075] A total of 1000 pieces were made

[0076] Concrete preparation method is as follows:

[0077] Weigh azithromycin, erythrose, aspartame, menthol, and chocolate powder essence that have passed through a 100-mesh sieve, mix well, add an appropriate amount of 50% ethanol solution to granulate, and mix low-substituted hydroxypropyl cellulose, microcrystalline cellulose , citric acid and sodium bicarbonate are mixed evenly with dry granules, a...

Embodiment 3

[0078] Example 3: Preparation of Azithromycin Orally Disintegrating Tablets

[0079] Component Weight Weight %

[0080] Azithromycin 125g 31.25%

[0081] Erythrose 125g 31.25%

[0082] Aspartame 4g 1%

[0083] Menthol 2g 0.5%

[0084] Chocolate Powder Flavor 8g 2%

[0085] 50% ethanol appropriate amount

[0086] Crospovidone 40g 10%

[0087] Microcrystalline Cellulose 80g 20%

[0088] Citric acid 8g 2%

[0089] Sodium bicarbonate 4g 1%

[0090] Magnesium Stearate 4g 1%

[0091] Total weight 400g

[0092] A total of 1000 pieces were made

[0093] Concrete preparation method is as follows:

[0094] Weigh azithromycin, erythrose, aspartame, menthol, and chocolate powder essence that have passed through a 100-mesh sieve, mix well, add an appropriate amount of 50% ethanol to granulate, and mix crospovidone, microcrystalline cellulose, and citric acid And sodium bicarbonate and dry granules are mixed evenly, and magnesium stearate is added after the semi-finished produc...

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PUM

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Abstract

An oral disintegrating tablet of azimycin is prepared from azimycin, water-soluble filler, disintegrant, lubricant, and wetting agent or adhesive.

Description

technical field [0001] The invention relates to an azithromycin orally disintegrating tablet and a preparation method thereof. technical background [0002] Azithromycin is a macrolide antibiotic, which achieves antibacterial effect by inhibiting the synthesis of ribosomal 50S subunit protein in bacterial cells. Azithromycin can inhibit a variety of Gram-positive cocci, Mycoplasma, Chlamydia and Legionella pneumophila, especially has good antibacterial activity against some important Gram-negative bacilli such as Haemophilus influenzae. Azithromycin is widely used clinically in the treatment of respiratory tract infections, skin and soft tissue infections, and genitourinary system infections. [0003] The structural formula of azithromycin is as follows [0004] [0005] Currently, the dosage forms of azithromycin in clinical use include ordinary tablets, capsules, suspensions, injections, granules, etc. Most of these oral dosage forms need to be taken with water, and i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7052A61K9/20A61P31/04
Inventor 杨丽英高玉清申东民张晓鹏
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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