Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

N-acetylcysteine compositions for the treatment and prevention of drug toxicity

A technology of acetylcysteine ​​and composition, applied in the field of treatment or prevention of such poisoning, can solve problems such as drug toxicity reaction

Inactive Publication Date: 2009-03-04
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Long-term use of antibiotics also often produces drug toxicity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] For febrile children or adults, treat with a formulation containing 15 mg / kg acetaminophen and 1 mg / kg N-acetylcysteine. Among them, the purified L-enantiomer of N-acetylcysteine, or its racemic ester mixture composed of D- and L-isomers in equal proportions, is used. Or administration in stages, or co-administration. 3-4 times daily, up to the highest tolerated dose, due to individual variability in tolerance to N-acetylcysteine. The dose of N-acetylcysteine ​​can vary between 0.3-4 times the dose used for acetaminophen.

Embodiment 2

[0059] Febrile children or adults who do not respond to acetaminophen at standard dose levels can be treated with a formulation containing 15-50 mg / kg acetaminophen and 3-130 mg / kg N-acetylcysteine, where, Use either the purified L-enantiomer of N-acetylcysteine, or its racemic ester mixture consisting of equal proportions of the D- and L-isomers. Or administration in stages, or co-administration. 3-4 times daily, up to the highest tolerated dose, due to individual variability in tolerance to N-acetylcysteine.

Embodiment 3

[0061] Normal dose levels of acetaminophen can be used for several days in a healthy child or adult with a low-grade fever. This preparation contains 80 mg of paracetamol per tablet, and 3 mg of N-acetylcysteine ​​per tablet, wherein the purified L-enantiomer of N-acetylcysteine ​​is used, or the other A mixture of racemic esters consisting of proportional D- and L-isomers. Or administration in stages, or co-administration. 3-4 times daily, up to the highest tolerated dose, due to individual variability in tolerance to N-acetylcysteine. The number of tablets depends on the patient's condition and weight.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a pharmaceutical composition for treating or preventing the toxic effects of therapeutic drugs, and the use of N-acetylcysteine ​​(alone or in combination with a therapeutically effective amount or higher than the usual therapeutically effective amount) that can reduce the toxicity of the drug. used in combination with sexual agents) to achieve its therapeutic superiority. The present invention also provides a pharmaceutical composition for the treatment or prevention of the toxic effects of therapeutic drugs, and the use of N-acetylcysteine ​​(either alone, or with a therapeutically effective amount or higher than the usual dose of N-acetylcysteine) that can reduce toxicity. The therapeutic advantages of therapeutic agents) whose side effects are exacerbated by increased oxidative stress, or a treatment-related decrease in the patient's cysteine / glutathione levels, or may be Relieved by administration of NAC.

Description

[0001] scope of invention [0002] The present invention relates to a composition for treating or preventing mammals including humans from drug poisoning caused by taking therapeutic agents, and a method for treating or preventing such poisoning. The composition of the present invention comprises an amount of N-acetylcysteine ​​(NAC) capable of reducing intoxication, used alone or in combination with a therapeutically effective amount or greater than the usual therapeutically effective amount of a therapeutic agent to achieve its therapeutic advantage, It is best used in combination with pharmaceutically acceptable carriers. A method for treating or preventing drug poisoning in humans, comprising taking a toxicity-reducing amount of N - Acetylcysteine, which is preferably combined with a pharmaceutically applicable carrier. [0003] government support [0004] This research was supported at least in part by grant N.I.H.CA42509-14. The government has certain rights in this i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61K31/10A61K31/70A61P39/02A61K31/277A61K31/167A61K31/198A61K31/223A61K31/7072A61P29/00A61P31/04A61P31/12A61P31/18A61P39/00A61P43/00
CPCA61K31/198A61K31/7072A61P29/00A61P31/04A61P31/12A61P31/18A61P39/00A61P39/02A61P43/00
Inventor 莱纳德·A·赫泽恩伯格S·C·德索萨J·安德鲁斯里奥铙雷·A·赫泽恩伯格
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com