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Method for preparing phosphate eritrocina using eritrocina

A technology of erythromycin phosphate and erythromycin, which is applied to the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of easy precipitation of crystals, difficult operation, high cost, etc., and achieve short process route and easy operation Simple, low-cost effect

Active Publication Date: 2008-11-19
XIAN LIJUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with this process, crystals are easily precipitated during the reaction, the yield is high, and the operation is difficult.

Method used

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  • Method for preparing phosphate eritrocina using eritrocina
  • Method for preparing phosphate eritrocina using eritrocina

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Add 20g of erythromycin to 500ml of n-butyl acetate organic solvent, stir, add dropwise 3.2ml of 60% phosphoric acid-n-butyl acetate solution to adjust the pH value to the reaction end pH4.5, control the reaction temperature at 10°C, and finally After centrifugation and oven drying, the white powder of erythromycin phosphate was obtained.

Embodiment 2

[0060] Add 12g of erythromycin to 250ml of isobutyl acetate organic solvent, stir, add dropwise 10ml of 15% phosphoric acid-isobutyl acetate solution to adjust the pH value to the reaction end point pH4.0, control the reaction temperature to 12°C, and finally wash with water The reactants were separated and dried to obtain white powder of erythromycin phosphate.

Embodiment 3

[0062] Add 80g of erythromycin to 80ml of ethanol organic solvent, stir, add 16ml of 45% phosphoric acid-ethanol solution dropwise to adjust the pH to pH 8.0 at the end of the reaction, control the reaction temperature to 15°C, and finally spray and dry to obtain erythromycin phosphate Plain white powder.

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Abstract

The invention relates to a Method for preparation of erythrocin salt, especially a method on using erythrocin to prepare phosphoric acid erythrocin. The characters are: dissolving erythrocin in organic solventn or water of c2-c6 containing hydroxyl group and carbonyl group, agitating, controlling the reaction temperature of forming salt, carrying through synthesize reaction by dripping phosphoric acid solution to regulate the solution's pH value and control reflecting terminal, finally, getting phosphoric acid erythrocin finished product after separation and desiccation. Its technology is advanced, the hazardness for people and circumstance is small, the productivity is high, the cost is low.

Description

technical field [0001] The invention relates to a method for preparing erythromycin salt, in particular to a method for preparing erythromycin phosphate by using erythromycin. Background technique [0002] Erythromycin phosphate is the phosphate of erythromycin, a new type of veterinary drug that has only been used in recent years. It has the same effect as erythromycin thiocyanate, odorless erythromycin, ettoerythromycin, and erythromycin acetate, and its efficacy is equivalent to that of erythromycin. It is mainly used for the treatment of inflammation in animals. Erythromycin and its derivatives are broad-spectrum macrolide antibiotics widely used in clinical practice. They have strong antibacterial effects on Gram-positive bacteria and are used for infections caused by sensitive Gram-positive cocci. The antibacterial mechanism is by binding to the 50S subunit of the sensitive bacterial ribosome, blocking the transpeptidation and the displacement of mRNA. Antibacterial ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/02
Inventor 陈晓军齐拴武郑飞张玉良孙建敏王国维文美乐胡麦霞王健邓弘关惠娟吴湘明
Owner XIAN LIJUN PHARMA CO LTD
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