Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation technique of absorbent hydroxyapatite artificial bone

A hydroxyapatite and preparation process technology, which is applied in medical science, prosthesis and other directions, can solve the problems of high requirements on corrosion resistance of the reactor, unsatisfactory treatment effect, harsh reaction conditions, etc., and achieves remarkable medical effect, Light weight and the effect of expanding the hole surface

Inactive Publication Date: 2008-04-30
梁辉 +2
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pure hydroxyapatite produced by this method has the disadvantage that it requires relatively high reaction conditions. It is carried out under high temperature and high pressure conditions, and the reaction conditions are relatively harsh. Moreover, the reaction produces pure hydroxyapatite, which lacks biological activity and cannot be gradually absorbed and transformed into autologous bone, so the therapeutic effect is not ideal.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation technique of absorbent hydroxyapatite artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: 1. Get 2 kilograms of natural corals, soak them in fresh water for two days, grind them into shape with an electric sand wheel, soak them in tap water for one day to remove organic matter, and scrub the surface to remove organic matter in the corals. ② Use 10 kg of 0.001% dilute hydrochloric acid to etch the coral channel to make the surface of the channel rough. Measure the diameter of the channel under an optical microscope and control it at about 200 μm. ③Take 2 kg of saturated diammonium hydrogen phosphate salt solution to soak the coral, and place it in a 5 kg chemical synthesizer (reactor), and react in the synthesizer at 140°C for 48 hours under a pressure of 3Mpa to obtain a composite Artificial bone. ④ The product is microwave-dried for 30 minutes, packed in double-layer plastic bags, and then sterilized with high-energy gamma rays 600rad after sealing.

[0017] Experiments show that: under the highest pressure (3Mpa) and the lowest temperature (...

Embodiment 2

[0018] Example 2: ①②④ are the same as in Example 1, and ③reaction conditions are changed to 180°C for 48 hours under a pressure of 3Mpa to obtain an artificial bone.

[0019] Experiments show that under the highest pressure (3Mpa) and highest temperature (180°C), the coral replacement reaction is carried out in the shortest time (48 hours). The artificial bone contains 89% of coral hydroxyapatite crystals, triphosphate Calcium 11%, porosity reaches 52%.

Embodiment 3

[0020] Example 3: ①②④ are the same as in Example 1, ③reaction conditions are changed to 140° C. for 72 hours under a pressure of 0.3 MPa.

[0021] Experiments show that under the lowest pressure (0.3Mpa) and the lowest temperature (140°C), the coral replacement reaction takes the longest time (72 hours). The artificial bone contains 81% of coral hydroxyapatite crystals, Tricalcium phosphate 19%, porosity reaches 50%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
porosityaaaaaaaaaa
porosityaaaaaaaaaa
porosityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a technique for preparing absorbent hydroxyl apatite artificial bone which comprises the following steps: washing, rinsing and drying natural coral, etching its openings by hydrochloric acid, immersing it by saturated phosphate solution, putting them at reaction still to react on the condition: 0.3-3Mpa, 140 -180 deg. for 48-72 hours to obtain the artificial bone which has crystal coral hydroxyl apatite 80%-90% and triohosphate 10%20%.

Description

technical field [0001] The invention relates to a preparation process of artificial bone, which belongs to the field of medical materials, in particular to a preparation process for converting natural coral into composite artificial bone. Background technique [0002] The repair of bone defects due to various reasons, especially the repair of large bone defects, has always been an important research direction of bone reconstruction and repair. In the past, bone graft materials used allogeneic bone, xenogeneic bone or hydroxyapatite, allogeneic calcined bone, etc., and the prepared materials had no pores or poor pore traffic, and there were many blind pores between the channels or the porosity rate varied greatly. Pore ​​traffic cannot meet the structural requirements of bone tissue growth, and the immunogenicity of allogeneic bone and xenogeneic bone cannot be solved, so the therapeutic effect in clinical application is not ideal. In recent years, people's research on bone ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12
Inventor 孟志斌
Owner 梁辉
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com