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Primer for dental materials and pulp capping agent for dentin regeneration

A technology of dental materials and primers, applied in dental preparations, dentistry, dental prostheses, etc., can solve problems such as the ability to regenerate dentin that cannot be expected

Inactive Publication Date: 2007-11-28
THE NIPPON SYNTHETIC CHEM IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dental primer described in this patent document contains a polymerizable monomer having an acidic group such as a phosphoric acid group, a carboxylic acid group, a sulfonic acid group, a phosphonic acid group, etc., so the ability to regenerate dentin cannot be expected.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] After irradiating ozone to ethylene-vinyl acetate copolymer saponified product particles (ethylene content 29 mol%, saponification degree 99.7 mol%, average degree of polymerization 450, no boric acid added) with an average particle diameter of 1 μm, carboxyl groups were introduced on the surface (introduced amount 0.86 μmol cm -2 ), diluted with 5 mM phosphoric acid aqueous solution (pH: 3.7, manufactured by Nitta Gelatin Inc.), commercially available bovine-derived tissue repair collagen (5 mM phosphoric acid solution containing 0.94%, pH 3.7, manufactured by Nitta Gelatin Inc.), The prepared 0.5% collagen-containing phosphoric acid solution was dipped and stirred at 25° C. for 16 hours to immobilize collagen on the surface of ethylene-vinyl acetate copolymer saponified product particles. The fixed amount of collagen is 20 μg cm -2 .

[0093] The primer for dental materials of the present invention was prepared by mixing 10 parts of the prepared collagen-fixed ethyl...

Embodiment 2

[0100] In Example 1, except that fine particles having an ethylene content of 29 mol%, a degree of saponification of 99.7 mol%, an average degree of polymerization of 450, and an added amount of boric acid of 0.03 parts by weight were used as the saponified product of ethylene-vinyl acetate copolymer, other evaluations were performed in the same manner. As a result, the pulp portion of the exposed pulp cavities group used in the example had no inflammation at all, and the thickness of the regenerated dentin layer was 650 μm. Furthermore, the amount of carboxyl group introduced at this time was 1.30 μmol·cm -2 , The fixed amount of collagen is 30μg·cm -2 .

Embodiment 3

[0102] In Example 1, in addition to using ethylene-vinyl acetate copolymer saponified products with an ethylene content of 29 mol%, a degree of saponification of 99.7 mol%, an average degree of polymerization of 450, and an addition of boric acid in an amount of 0.03 parts by weight, the addition of the particles was Other than 20 samples were evaluated in the same manner. In the pulp cavity group used in the example, there was no inflammation at all in the pulp part, and the thickness of the regenerated dentin layer was 680 μm.

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Abstract

The present invention provides a dental material primer and a dentin-regenerating pulp-capping agent which exhibit excellent a dentin-regenerating action. The present invention relates to the dental material primer comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent comprising a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.

Description

technical field [0001] The invention relates to a primer for dental materials and a dentin regeneration pulp capping agent with dentin regeneration ability for treating carious teeth. Background technique [0002] Conventionally, carious teeth have been treated by removing the carious portion of enamel or dentin, and embedding metal or resin in the portion for treatment. However, in this case, the pulp may be exposed at the portion where the dentin was removed. [0003] In this case, if metal or resin is directly used to cover the pulp part, it is because the adhesion between the pulp and the metal or resin is insufficient, or bacteria enter between the pulp and the metal or resin to cause inflammation. Painful, so expect the pulp to be covered with regenerated dentin. [0004] As a method of regenerating dentin, there is a method of using calcium hydroxide preparation as a pulp capping agent on the exposed pulp, but the pulp surface in contact with calcium hydroxide will h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/083A61K6/027A61K6/08A61C8/00A61C13/00A61L27/00C08L23/00C08L29/00C08L31/00A61K6/884
Inventor 吉山昌宏西谷佳浩堤定美玄丞烋
Owner THE NIPPON SYNTHETIC CHEM IND CO LTD
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