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Preparation method of astilbin

An astilbin, weight technology is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve problems such as waste of resources, and achieve the effects of low cost, high purity and simple extraction process

Inactive Publication Date: 2007-11-14
CHIA TAI TIANQING PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the amount of astilbin contained in the leaves of Huangqi trees grown in Guangxi, Guizhou and other places in China is several times that of Smilax smilax, and Huangqi leaves have only been used as tea leaves for a long time in the local area, which is obviously a waste of precious Resources

Method used

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  • Preparation method of astilbin

Examples

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Effect test

Embodiment 1

[0020] Example 1: Pulverize the medicinal material of Huangqi leaf into coarse powder, extract by percolation with 95% ethanol 10 times the weight of the material and 80% ethanol 15 times the weight, and collect the percolation liquid. 95% ethanol extract is degreased with petroleum ether, concentrated to extract, added ethanol to make the solution concentration 20% ethanol aqueous solution, after dissolving, place to precipitate, separate the precipitate, combine mother liquor with 80% ethanol extract, concentrate to each 3 grams of crude drug in milliliters is extracted with ethyl acetate equivalent to 2 times the amount of crude drug, the ethyl acetate extract is concentrated to extractum, and aqueous ethanol solution is added to make the solution concentration 20% ethanol aqueous solution, which is left to precipitate after dissolving. Separate the precipitate, combine the precipitates obtained from the two alcohol precipitations, pass through the polyamide column after dis...

Embodiment 2

[0021] Embodiment 2: Pulverize the medicinal material of Huangqi leaf into a coarse powder, use 15 times of the weight of the material to extract 90% ethanol and 10 times the amount of 60% ethanol by percolation, collect 90% ethanol extract and 60% ethanol extract, and extract with 90% ethanol After the liquid is degreased with petroleum ether, the extract is concentrated to an extract, and ethanol is added to make the solution concentration 60% by weight of ethanol aqueous solution, dissolved, placed to precipitate, and the 60% ethanol extract is combined with the mother liquor after the aforementioned alcohol precipitation, and concentrated with Extract with ethyl acetate with 5% ethanol, concentrate the ethyl acetate extract to the extract, add ethanol to make the ethanol concentration 60%, leave it to precipitate after dissolving, combine the precipitates obtained from the two alcohol precipitations, dissolve in water and pass through LSA-10 Macroporous resin (produced by X...

Embodiment 3

[0022] Example 3: Pulverize the medicinal material of Huangqi leaf, extract by gradient percolation with 20 times the weight of the material 95% ethanol and 8 times the amount of 20% ethanol, collect 95% ethanol extract and 40% ethanol extract respectively, and use petroleum ether for the 95% ethanol extract After degreasing, concentrate the extract to the extract, dissolve it in water and place it to precipitate, combine and concentrate the 40% ethanol extract with the mother liquor after alcohol precipitation, then extract with ethyl acetate containing 20% ​​ethanol, and concentrate the ethyl acetate part to the extract Finally, add ethanol to make the ethanol concentration 80%, put it aside after dissolving, combine the precipitates obtained by two alcohol precipitations, dissolve in water, pass through a polyamide column, and elute with 50% ethanol solution. After the eluent evaporates the solvent, 70% ethanol Astilbin monomer was obtained by recrystallization. After recrys...

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Abstract

The invention provides a process for preparing astilbin which comprises the steps of disintegrating medicinal materials, extracting with aqueous solutions of ethanol with two concentrations, degreasing the 90-95 wt% water raffinate of ethanol with petroleum ether, condensing into concrete, alcohol-depositing the concrete, merging the mother liquid with 20-80 wt% water raffinate of ethanol, concentrating and extracting with ethanol-containing acetic ester liquid, alcohol-depositing the extract and mixing with the precipitation, dissolving then passing through macro-porous absorption resin or polyamide columns, eluting with 20-80 wt% aqueous solution of ethanol, finally recrystallizing the eluent. The extraction rate of astilbin is over 50%, and the content of astilbin is over 90%.

Description

1. Technical field [0001] The invention relates to a method for preparing astilbin from Chinese medicinal material Huang Qi Ye (Engelhardria roxburghiana Wall). 2. Background technology [0002] Astilbin (astilbin) 3, 3, 4', 5, 7-pentahydroxyflavanone3-(6-deoxy-(L-mannopyranoside)) is a flavonoid compound, which was first obtained from the plant Astilbin in 1950 by Kozo Hayashi and Kazuhiko Ouchi extracted. The structural formula of astilbin is as follows: [0003] [0004] As reported in the literature, astilbin has insecticidal properties (Pest Manag.Sci.2002; 58:503-507), inhibition of coenzyme A reductase (Zhonghua Yi Xue Za Zhi (Taipei) 2001; 64:382-387), inhibition of aldose Reductase (Biosci.Biotechnol.Biochem.1997; 61:651-654,), hepatoprotective (Prostaglandins Leukot Essent Fatty Acids 1997; 56:331-334), analgesic, anti-edema (Arzneimittelforschung 2000; 50:281-285 ), antioxidation (Biosci.Biotechnol.Biochem.1996; 60:513-515), and astilbin can also significant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 陈婷姚毅徐强
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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