Transdermal preparation
a technology of transdermal preparation and adhesive, which is applied in the field of transdermal preparation, can solve the problems of reducing the content of basic drugs, difficulty in containing basic drugs with 10 mass % or more in these adhesives, and affecting the effect of skin permeation rate, and good time-course stability of drugs
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[0080]In the following, the present invention is explained in more details by way of examples. The present invention, however, is not limited to these examples. Furthermore, “%” means “mass %” unless otherwise expressly stated.
Evaluation of Drug Reservoir Layer
[0081]
TABLE 1Ex. 1Ex. 2Ex. 3Ex. 4Ex. 5Ex. 6Ex. 7Polyvinyl60%55%50%————pyrrolidone(low molecularweight)Polyvinyl———60%55%50%—pyrrolidone(high molecularweight)Hydroxypropyl————60%celluloseEudragit (R) EPO———————Acrylic adhesive———————(—COOHgroup-containingtype)Bisoprolol40%45%50%40%45%50%40%Comp.Comp.Comp.Ex. 8Ex. 9Ex. 10Ex. 11Ex. 12Ex. 1Ex. 2Ex. 3Polyvinyl————————pyrrolidone(low molecularweight)Polyvinyl————————pyrrolidone(high molecularweight)Hydroxypropyl55%50%——————celluloseEudragit (R) EPO——60%55%50%———Acrylic adhesive—————60%55%50%(—COOHgroup-containingtype)Bisoprolol45%50%40%45%50%40%45%50%Comp.Comp.Ex. 13Ex. 14Ex. 4Ex. 5Hydroxypropyl80%85%——celluloseAcrylic adhesive——80%85%(—OHgroup-containingtype)Fluvoxamine20%15%20%15%...
examples 1-14
[0082]In accordance with the mix ratio listed in the above table of formulation, ethanol was added and dissolved into each polymer, and bisoprolol or fluvoxamine was added and stirred sufficiently to give a coating solution. Then, the obtained coating solution was coated on a polyethylene terephthalate release film, the ethanol as the solvent was removed by drying, to form an adhesive layer. After obtaining a predetermined thickness (200 μm), the adhesive layer was laminated with a polyethylene terephthalate backing, giving a transdermal preparation (Examples 1-14) of the present invention.
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