Faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain
a technology of gastrointestinal pain and faecalibacterium prausnitzii, which is applied in the field of faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain, can solve the problems of ibs being poorly understood, affecting the effect of gastrointestinal pain, and the current treatment of ibs and visceral abdominal pain is disappointing
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[0118]F. prausnitzii strains according to the invention have been tested for their ability to have a direct impact on visceral pain, and more particularly on colonic hypersensitivity.
[0119]Bacterial Strains Isolation and Growth Conditions
[0120]The F. prausnitzii strains isolates used in the present example all are of human fecal origin from healthy patients. Said isolates were obtained from the highest countable dilution of human fecal samples in roll tubes of anaerobic M2GSC medium as discussed in Lopez-Sites et al. (Appl. Environ Microbiol. 2012; 78:420-428).
[0121]Tested F. prausnitzii strains isolates were grown in LYBHI medium (Brain-Heart infusion medium supplemented with 0.5% yeast extract) (Dyfco, Detroit, USA) supplemented with 1 mg / mL cellobiose (Sigma-Aldrich Chemie Gmbh, Buchs, Switzerland), 1 mg / mL maltose (Sigma-Aldrich) and 0.5 mg / mL cysteine (Sigma-Aldrich) at 37° C. in anaerobic chamber.
[0122]A. In a first series of tests, a Neonatal Maternal Separation (NMS) colonic...
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