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Manufacturing Method For and Insecticidal Compositions Comprising Thiocyclam Hydrochloride

a technology of thiocyclam hydrochloride and composition, which is applied in the field of manufacturing methods for and insecticidal compositions comprising thiocyclam hydrochloride, can solve the problems of affecting the life of insects, affecting the health of people, pets, and the environment, and each insecticide can pose a different level of risk to non-target insects, people, pets and the environment. , to achieve the effect of improving the insecticidal composition,

Inactive Publication Date: 2018-03-22
ARYSTA LIFESCIENCE NORTH AMERICA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a method for making thiocyclam hydrochloride with a yield of over 30%. Additionally, the invention provides an improved insecticide composition that is effective at a low dose of thiocyclam hydrochloride and / or solvate thereof.

Problems solved by technology

Some insecticides disrupt the nervous system, whereas others may damage their exoskeletons, repel them or control them by some other means.
Because of these factors, each insecticide can pose a different level of risk to non-target insects, people, pets and the environment.
Nearly all insecticides have the potential to significantly alter ecosystems; many are toxic to humans and some concentrate along the food chain.
Contact insecticides are toxic to insects upon direct contact.
Each of these current treatments and methods has one or more drawbacks, including toxicity, cost, availability, reliability, and high application amounts.
New insecticidal compositions also face elevated government regulations and public scrutiny as to their environmental and ecological impacts.

Method used

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  • Manufacturing Method For and Insecticidal Compositions Comprising Thiocyclam Hydrochloride
  • Manufacturing Method For and Insecticidal Compositions Comprising Thiocyclam Hydrochloride
  • Manufacturing Method For and Insecticidal Compositions Comprising Thiocyclam Hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

example 5

[0053]An aqueous saline solution of Na2S.9H2O (239.5 g) was added to a stirring mixture of Monosultap (350 g), sodium hydroxide (39.9 g) and toluene / saline over 3.5 hours maintaining the temperature at −16 to −18° C. The reaction mixture was stirred at −16 to −18° C. until complete then filtered to remove inorganic salts. The cake was washed with toluene and the wash was combined with the filtrates. The phases were separated and the toluene solution was washed with water, then brine, and dried over sodium sulfate. 2M ethereal hydrochloric acid (680 mL) was added to the batch over 30 minutes and the mixture was stirred for 1 hour. The solids formed were collected by filtration, washed with ice-cold MTBE and dried to give thiocyclam hydrochloride in 33% yield (76.1 g) and 95.2% purity with 0.05% residual toluene.

[0054]The starting material in this novel reaction is Monosultap, which is a trade name for thiosulfuric acid S,S′-[2-(dimethylamino)trimethylene] ester monosodium salt, avail...

example 1

[0094]Codling Moth, Cydia pomonella—Neonate Larvae

[0095]Bioassay by diet incorporation

[0096]Mortality assessment 2 days after treatment.

[0097]a.i. refers to active ingredient

LC50LC90(μg of (μg of Puritya.i. / mla.i / ml ofof ofD + 2a.i.diet)minmaxdiet)MinmaxCartap  50%10.147.9812.87104.8074.72157.80Thiocyclam87.5% 3.573.00 4.25 19.7615.53 26.32oxalate Thiocyclam 100% 2.572.14 3.09 10.80 8.41 14.79HCl

example 2

[0098]Soybean Looper, Chrysodeixis includens—3rd Larval Stage

[0099]Bioassay by diet surface incorporation

[0100]Mortality assessment 3 days after treatment

[0101]a.i. refers to active ingredient

LC50(μg of a.i. / mlLC90D + 3Purity of a.i.of diet)minmax(μg of a.i. / ml)MinmaxCartap  50%53,06931,907106,810908,897346,4734.64 × 106Thiocyclam87.5%173,36352,5292.38 × 1068.55 × 106906,9141.53 × 109oxalateThiocyclam 100%8,9926,52012,564251,759145,956504,401HCl

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Abstract

A method for manufacturing an insecticidal compound and insecticidal compositions comprising the insecticidal compound and methods of use are presented herein. The manufacturing method presented herein allows for a high purity grade of thiocyclam hydrochloride to be synthesized. The insecticidal compositions comprising the thiocyclam hydrochloride can be used for prevention of crop destruction by insects. The use of thiocyclam hydrochloride in insecticidal compositions as described herein can achieve greater efficacy than previously known insecticides, by eliminating the insect pests more reliably and efficiently.

Description

FIELD OF THE INVENTION[0001]Embodiments herein relate generally to the manufacturing and use of the compound thiocyclam hydrochloride and / or solvate thereof, to control insect pests on plants, plant parts and locus thereof, including agricultural crops.BACKGROUND OF THE INVENTION[0002]Insecticides are pesticides that are formulated to kill, harm, repel or mitigate one or more species of insect. Insecticides work in different ways. Some insecticides disrupt the nervous system, whereas others may damage their exoskeletons, repel them or control them by some other means. They can also be packaged in various forms including sprays, dusts, gels, and baits. Because of these factors, each insecticide can pose a different level of risk to non-target insects, people, pets and the environment.[0003]Insecticides are chemicals used to control insects by killing them or preventing them from engaging in behaviors deemed undesirable or destructive. They are classified based on their structure and ...

Claims

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Application Information

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IPC IPC(8): C07D341/00A01N43/32A01N43/80
CPCC07D341/00A01N43/80A01N43/32
Inventor GIBB, CAMERON S.LARSON, CHRISTOPHER L.SINGLETON, MARK T.KATARIA, KAMAL L.BESSE, SAMANTHAMOORE, III, JOSEPH A.LOVELACE, THOMAS C.KANUGALA, CHANDRA S.VOLLALA, SRINIVASVADLA, BALRAJU
Owner ARYSTA LIFESCIENCE NORTH AMERICA LLC
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