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Peptides for targeting gastric cancer, and medical use tehreof

a technology of peptides and gastric cancer, applied in the field of peptides for targeting gastric cancer, can solve the problems of cell death by itself, differences in the case of respective patients, and concerns about immune respons

Inactive Publication Date: 2017-11-09
UNIV OF ULSAN FOUND FOR IND COOPERATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a peptide that targets stomach cancer caused by genetic differences in patients. The peptide can be used to diagnose the responsiveness of cancer to radiation therapy, and to develop targeted therapy for individual patients. The invention involves creating animal models that mimic the cancer environment, and testing the peptides for their ability to specifically target cancer cells. The results can be used to develop personalized therapy for patients with stomach cancer.

Problems solved by technology

However, if cells are not recovered, cells die by themselves.
However, there are problems during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients having cancer.
However, in the case of antibodies, there are problems including concerns of immune response and low efficiency of penetration into tissues.

Method used

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  • Peptides for targeting gastric cancer, and medical use tehreof
  • Peptides for targeting gastric cancer, and medical use tehreof
  • Peptides for targeting gastric cancer, and medical use tehreof

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Embodiment Construction

Technical Problem

[0005]The present invention, unlike screening methods that have been studied at the existing cell culture levels, establishes mouse models transplanted with a cancer tissue of an actual human, to thereby divide them into an irradiated population and a non-irradiated population as a control group. In addition, a method of screening a peptide that specifically binds to each population above is disclosed to provide a novel peptide for targeting gastric cancer and a medical use of such a novel peptide.

Technical Solution

[0006]To solve the technical problem above, the present invention provides a peptide for targeting gastric cancer and a polynucleotide encoding the peptide, the peptide including an amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 6.

[0007]In an embodiment, the present invention provides a peptide for targeting gastric cancer, the peptide including an amino acid selected from the group consisting of SEQ ID NOs: 1 to 3.

[0008]In an ...

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PUM

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Abstract

Provided is a peptide for targeting gastric cancer, a composition for diagnosing radioresponsiveness-dependent gastric cancer using the peptide, and a drug delivery use of the peptide, wherein a functional peptide capable of targeting cancer has been discovered so as to implement personalized diagnosis and treatment for individual patients having cancer, consideration of problems occurring during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients.

Description

TECHNICAL FIELD[0001]The present invention relates to a peptide for targeting gastric cancer, a composition for diagnosing gastric cancer based on performance of irradiation using the peptide, and drug delivery use of the peptide.BACKGROUND ART[0002]Cells which are the smallest unit of the human body maintain the balance of cell number by cell division upon intracellular regulatory functions, cell growth, and cell death and disappear, when cells are normal. If the cells are damaged by any cause, cells may be recovered by treatment to thereby serve as normal cells. However, if cells are not recovered, cells die by themselves. A condition in which abnormal cells that do not control proliferation and inhibition thereof for a variety of reasons are excessively proliferated and also cause tumefaction and destruction of normal tissues by invading surrounding tissues and organs is defined as cancer. As such, cancer refers to cell proliferation that is not inhibited, and cancer destroys the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/574G01N33/58C07K7/08A61K47/00A61K49/00G01N33/00
CPCG01N33/574G01N33/58A61K47/00G01N33/00A61K49/00C07K7/08A61K49/0004A61K49/0008G01N33/57446
Inventor CHOI, EUN KYUNGJEONG, SEONG-YUNSONG, SI YEOLLEE, KYOUNG JINSHIN, SEOL HWAJU, EUN JIN
Owner UNIV OF ULSAN FOUND FOR IND COOPERATION
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